Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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CCNU, Vinblastine and Prednisone Treatment for Grade II Dermal Mast Cell Tumor in a Yorkshire terrier dog

CCNU, Vinblastine과 Prednisone으로 병용 치료한 요크셔 테리어 개의 Grade II 피부 비만세포종 증례

  • Seo, Kyoung-Won (College of Veterinary Medicine, Seoul National University) ;
  • Lee, Jong-Bok (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Seoung-Soo (College of Veterinary Medicine, Seoul National University) ;
  • Bhang, Dong-Ha (College of Veterinary Medicine, Seoul National University) ;
  • Jung, Jin-Young (College of Veterinary Medicine, Seoul National University) ;
  • Hwang, Cheol-Yong (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Dae-Yong (College of Veterinary Medicine, Seoul National University) ;
  • Youn, Hwa-Young (College of Veterinary Medicine, Seoul National University) ;
  • Lee, Chang-Woo (College of Veterinary Medicine, Seoul National University)
  • Published : 2007.12.31
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Abstract

An 11-year-old, castrated male Yorkshire terrier dog was presented with multiple plaques on right inguinal region. Grade II mast cell tumor was diagnosed. The dog was treated with Vinblastine and prednisone(PDS) initially. Because of poor response of the dog, CCNU was added for more aggressive treatment. After 5 weeks treatment of with CCNU, vinblastine and PDS, the lesion was improved. Moderate leukopenia was shown after 4 cycles of chemotherapy. The chemotherapy was re-administered since the patient recovered from the leukopenia. Though the same protocol was applied, no improvement of the lesion was observed. Moreover, the general body condition of the dog became worse and was euthanized by the owner's request. Necropsy was not permitted. The survival time was 330 days after start of the chemotherapy.

11살의 중성화 수컷 요크셔 테리어 개가 오른쪽 서혜 부위에 다발성의 Plaque를 주증으로 내원하였다. 조직학적 검사를 통해 grade II의 비만 세포종으로 진단되었다. 초기 치료는 Vinblastine과 Prednisone을 사용하였다. 그러나 치료 반응이 좋지 않아 Lomustine(CCNU)를 첨가한 공격적인 치료를 실시하였다. CCNU, Vinblastine, PDS를 이용한 치료 5주 후에 병변은 개선되었다. 4차 항암치료 시 중등도의 백혈구 감소 증을 나타내었고, 이에 대한 개선 처치 후에, 같은 프로토콜을 적용한 항암치료를 실시하였으나, 병변이 개선되지 않았다. 이후, 환자의 전신적인 상태가 나빠져 보호자의 요청에 의해 안락사 하였으나 부검은 실시하지 못하였다. 환자의 생존기간은 항암치료 개시 후 330일 이었다.

Keywords

References

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