Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Serologic Survey for Canine Coronavirus in Adult Dogs

건강한 성견의 canine coronavirus에 대한 항체가 조사

  • Ahn, So-Jeo (School of Veterinary Medicine, Kangwon National University) ;
  • Jeoung, Seok-Young (School of Veterinary Medicine, Kangwon National University) ;
  • Pak, Son-Il (School of Veterinary Medicine, Kangwon National University) ;
  • Kim, Doo (School of Veterinary Medicine, Kangwon National University)
  • 안소저 (강원대학교 수의학부대학) ;
  • 정석영 (강원대학교 수의학부대학) ;
  • 박선일 (강원대학교 수의학부대학) ;
  • 김두 (강원대학교 수의학부대학)
  • Published : 2007.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

The purposes of this study were to survey the seroprevalence of canine coronavirus(CCV) in healthy adult dogs and to determine whether there was any relationship between seroprevalence and the host parameters. Serum samples for determination of serum neutralization antibody titers against CCV were obtained from 812 healthy adult dogs over 1 year old brought to veterinary clinics for routine health care visit in 4 provinces from January 2003 to April 2004. Of the 812 dogs, 714(87.9%) had positive antibody titers(more than 1:4) against CCV. The prevalence of positive CCV antibody titers were not significantly associated with age, sex, rearing province and environment, and vaccination status. However, the positive CCV antibody titers were increasing with the age. These serological findings have shown that prevalence of positive CCV antibody titers in Korean dogs were a relatively high and that CCV infection was widespread in Korean dog population. These suggest that it may be as important to protect dogs against infection with CCV as it is to vaccinate against canine parvovirus.

건강한 성견들의 혈청 CCV 항체 역가 보유실태와 역학적인 요인들과 관련성을 조사하기 위하여, 2003년 1월부터 2004년 4월까지 국내의 1세 이상된 성견 812두를 대상으로 CCV에 대한 중화항체 역가를 조사하였으며 연령, 성별, 사육지역, 사육환경 및 기초 예방접종과 추가 예방접종 여부 등의 역학적 요인들 별로 항체보유 상태를 조사하였다. 조사대상 812두의 성견 중 87.9%(714두)가 CCV에 대하여 항체 양성(1:4 이상) 반응을 보였다. 연령, 성별, 사육지역, 사육상태 및 예방접종 상태는 항체보유율에 영향을 미치지 않았으나 나아가 증가함에 따라 항체 보유율이 증가하는 양상을 보였다. 이상의 결과를 종합해볼 때, 국내의 성견들은 CCV에 대하여 항체보유율이 대체로 높은 수준이었으며 CCV 감염이 전국에 걸쳐 발생하는 것으로 판단되므로 개들의 CCV에 대한 방어를 위하여 위생적인 관리와 함께 예방접종이 필요한 것으로 생각되었다.

Keywords

References

  1. Appel MJ. Canine coronavirus. In: Virus infections of canivores. Amsterdam The Netherlands: Elsevier. 1987: 115-122
  2. Bandai C, Ishiguro S, Masuya N, Hohdatsu T, Mochizuki M. Canine coronavirus infections in Japan: Virological and epidemiological aspects. J Vet Med Sci 1999; 61: 731-736 https://doi.org/10.1292/jvms.61.731
  3. Barlough JE, Jacobson RH, Scott F. Macrotiter assay for coronavirus-neutralizing activity in cats using a canine continuous cell line (A-72). Lab Anim Sci 1983; 33: 567-570
  4. Barlough JE, Stoddart CA, Sorresso GP, Jacobson RH, Scott FW. Experimental inoculation of cats with canine coronavirus and subsequent challenge with feline infectious peritonitis virus. Lab Anim Sci 1984; 34: 592-597
  5. Binn LN, Eddy GA, Lazar EC, Keenan KP, Huxsoll DL, Marchwicki RH, Strano AJ. Recovery and characterization of a coronavirus from military dogs with diarrhea. Proceeding of the 78th Meeting of the US Animal Health Association 1974; 359-366
  6. Cartwright S, Lucas M. Vomiting and diarrhea in dogs. Vet Rec 1972; 91: 571-571 https://doi.org/10.1136/vr.91.23.571
  7. Decaro N, Martella V, Ricci D, Elia G, Desario C, Campolo M, Cavaliere N, Di Trani L, Tempesta M, Buonavoglia C. Genotype-specific fluorogenic RT-PCR assays of for the detection and quantitation of canine coronavirus type I and type II RNA in faecal samples of dogs. J Virol Methods 2005; 130: 72-78 https://doi.org/10.1016/j.jviromet.2005.06.005
  8. Horzinek MC, Lutz H, Pedersen N. Antigenic relationships among homologous structural polypeptides of porcine, feline, and canine coronaviruses. Infect Immun 1982; 37: 1148- 1155
  9. Hohdatsu T, Okada S, Ishizuka Y, Yamada H, Koyama H. The prevalence of types I and II feline coronavirus infections in cats. J Vet Med Sci 1992; 54: 557-562 https://doi.org/10.1292/jvms.54.557
  10. Kaneshima T, Hohdatsu T, Satoh K, Takano T, Motokawa K, Koyama H. The prevalence of a group 2 coronavirus in dogs in Japan. J Vet Med Sci 2006; 68: 21-25 https://doi.org/10.1292/jvms.68.21
  11. Lee BH, Jun MH, Huh W. Serologic survey for canine coronavirus infection in Korea. Korean J Vet Publ Hlth 1993; 17: 259-300
  12. Mochizuki M, Sugiura R, Akuzawa M. Micor-neutralization test with canine coronavirus for detection of coronavirus antibodies in dogs and cats. Jpn J Vet Sci 1987; 49: 563-565 https://doi.org/10.1292/jvms1939.49.563
  13. Mochizuki M, Hashimoto M, Ishida T. Recent epidemiological status of canine viral enteric infections and Giardia infection in Japan. J Vet Med Sci 2001; 63: 573-575 https://doi.org/10.1292/jvms.63.573
  14. Naylor MJ, Monckton RP, Lehrbach PR, Deane EM. Canine coronavirus in Australian dogs. Aust Vet J 2001; 79: 27-30
  15. Norman JO, McClurkin AW, Stark SL. Transmissible gastroenteritis (TGE) of swine: canine serum antibodies against and associated virus. Can J Comp Med 1970; 34: 115-117
  16. Pratelli A, Elia G, Martella V, PalmieriA, Cirone F, Tinelli A, Corrente M, Buanovoglia C. Prevalence of canine coronavirus antibodies by an enzyme-linked immunosorbent assay in dogs in the south of Italy. J Virol Methods 2002; 102: 67-71 https://doi.org/10.1016/S0166-0934(01)00450-5
  17. Pratelli A, Martella V, Decaro N, Tinelli A, Camero M, Cirone F, Elia G, Cavali A, Corrente M, Greco G, Bounavoglia D, Gentile M, Tempesta M, Buonavoglia C. Genetic diversity of a canine coronavirus detected in pups with diarrhoea in Italy. J Virol Methods 2003; 110: 9-17 https://doi.org/10.1016/S0166-0934(03)00081-8
  18. Pratelli A, Tinelli A, Drcaro N, Cirone F, Elia G, Roperto S, Tempesta M, Buonavoglia C. Efficacy of an inactivated canine coronavirus vaccine in pups. Microbiologica 2003; 26: 151-155
  19. Pratelli A. Genetic evolution of canine coroanvirus and recent advances in prophylaxis. Vet Res 2006; 37: 191-200 https://doi.org/10.1051/vetres:2005053
  20. Rimmelzwaan GF, Groen J, Egberink H, Borst GHA, UytdeHaag FGCM, Osterhaus ADME. The use of enzymelinked immunosorbent assay systems for serology and antigen detection on parvovirus, coronavirus and rotavirus infections in dogs in the Netherlands. Vet Micorobiol 1991; 26: 25-40 https://doi.org/10.1016/0378-1135(91)90039-I
  21. Sakulawira K, Vanapongtipagorn P, Theamboonlers A, Oraveerakul K, Poovorawan Y. Prevalence of canine coronavirus and parvovirus infections in dogs with gastroenteritis in Thailand. Vet Med 2003; 6: 163-167
  22. Sanchez-Morgado JM, Poynter S, Morris TH. Molecular characterization of a virulent canine coronavirus BGF strain. Lab Anim Sci 2004; 104: 27-31
  23. Sanchez CM, Jimenez G, Laviada MD, Correa I, Sune C, Bullido M, Gebauer F, Smerdou C, Callebaut P, Escribano JM. Antigenic homology among coronaviruses related to transmissible gastroenteritis virus. Virol 1990; 174: 410-417 https://doi.org/10.1016/0042-6822(90)90094-8
  24. Siddell S, Wege H, Ter Meulen V. The biology of coronaviruses. J Gen Virol 1983; 64: 761-776 https://doi.org/10.1099/0022-1317-64-4-761
  25. Spaan W, Cavanagh D, Horzinek MC. Coronaviruses; structure and expression. J Gen Virol 1988; 69: 2939-2952 https://doi.org/10.1099/0022-1317-69-12-2939
  26. Stoddart CA, Barlough JE, Baldwin CA, Scott FW. Attempted immunisation of cats against feline infectious peritonitis using canine coronavirus. Res Vet Sci 1988; 45: 383-388
  27. Tennant BJ, Gaskell RM, Jones RC, Gaskell CJ. Studies on the epizootiology of canine coronavirus. Vet Rec 1993; 132: 7-11 https://doi.org/10.1136/vr.132.1.7
  28. Woods RD, Cheville NF, Gallagher JE. Lesions in the small intestine of newborn pigs inoculated with porcine, feline, and canine coronaviruses. J Vet Res 1981;42: 1163-1169
  29. Woods RD, Pedersen NC. Cross-protection studies between feline infectious peritonitis and porcine transmissible gastorenteritis virus. Vet Microbiol 1979; 4: 11-16 https://doi.org/10.1016/0378-1135(79)90025-7
  30. Yesilbag K, Yilmaz Z, Torun S, Pratelli A. Canine coronavirus infection in Turkish dog population. J Vet Med B Infect Dis Vet Public Health 2004; 51: 353-355 https://doi.org/10.1111/j.1439-0450.2004.00773.x
  31. Yoon KB, Kang MI, Park DU. Seroepidemiological survey on canine distemper, canine parvovirus, canine coronavirus, canine adenovirus type-2, canine parainfluenzavirus of dogs by indirect immunofluorescent test. Korean J Vet Res 1995; 35: 75-85
  32. Zarnke LR, Evermann J, Ver Hoef JM, Mcnay ME, Boertje RD, Gardner C L, Adams LG, Dale BW, Burch J. Serologic survey for canine coronavirus in wolves from Alaska. J Wildlife Dis 2001; 37: 740-745 https://doi.org/10.7589/0090-3558-37.4.740