Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Effect of Extracts for Herbal Medicines on the Inhibition of Whole Blood Aggregation

한약재 추출물에 대한 전혈응집억제 효능 검색

  • Jeon, Won-Kyung (Department of Herbal Resources Research, Korea Institute of Oriental Medicine) ;
  • Yoo, Bo-Kyung (Herbal Quality Control Team, Korea Institute of Oriental Medicine) ;
  • Kim, Yeong-Eun (Herbal Quality Control Team, Korea Institute of Oriental Medicine) ;
  • Park, Sun-Ok (Herbal Quality Control Team, Korea Institute of Oriental Medicine) ;
  • Park, Sun-Min (Department of Food and Nutrition, Hoseo University) ;
  • Ko, Byoung-Seob (Herbal Quality Control Team, Korea Institute of Oriental Medicine)
  • 전원경 (한국한의학연구원 한약자원연구부) ;
  • 유보경 (한국한의학연구원 한약품질검사팀) ;
  • 김영은 (한국한의학연구원 한약품질검사팀) ;
  • 박선옥 (한국한의학연구원 한약품질검사팀) ;
  • 박선민 (호서대학교 식품영양학과) ;
  • 고병섭 (한국한의학연구원 한약품질검사팀)
  • Published : 2007.12.31
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Abstract

For a correlation to study the five tastes and efficacies in oriental medicine concepts, we used herbal medicines with bitter taste character in traditionally effective and experimental methods. In this study, we tested the in vitro effect of 20 typical kinds of herbal medicines with bitter taste on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry. Among them, 3 kinds of hot water extracts and 2 kinds of 70% ethanol extracts showed the significant inhibiting effect on whole blood aggregation $(^{***}p<0.001)$. In particular, Coptidis Rhizoma (Coptis chinensis) extracts were selected as the most effective candidate with a strong grade of bitter taste through the sensory test of trained panels. The results from this experiment provide pharmacological evidence for the traditional use of bitter tasting herbs with traditional medicine theory, suggesting that strong bitter taste herbs could be help problems of blood circulation more than mild bitter tasting herbs.

고미의 성질을 강하게 나타내는 한약재를 대상으로 맛과 효능과의 상관관계를 실험적으로 알아보기 위한 연구를 시도하였다. 본 연구에서는 콜라겐으로 유도된 인간전혈응집을 이용하여 고미약재 20품목에 대한 혈소판응집 억제능을 측정하였다. 이 중에 3종의 열수추출물과 2종의 70% 에탄올추출물이 p<0.001 수준에서 유의하게 전혈응집 억제 활성을 나타내었다. 특히, 전혈응집 억제능이 가장 뛰어난 후보소재로 황련이 선별되었으며 관능요원에 의한 관능평가에서 쓴맛이 가장 강한 한약재로 평가되었다. 이상의 실험결과는 전통의학이론을 바탕으로 한약재의 사용에 따른 효능을 실험적 근거로 제시할 수 있고 쓴맛이 약한 한약재보다 쓴맛이 강한 한약재가 혈액순환이 원활하게 하는 가능성의 경향이 있는 것으로 기대되었다.

Keywords

References

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