Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제33권1호
  • /
  • Pages.28-39
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  • 2007
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

Comparative histomorphologic study of regenerated bone for dental implant placement in the atrophied posterior maxilla

  • Kim, Se-Jung (Department of Oral and Maxillofacial Surgery, College of Dentistry, Kangnung National University) ;
  • Kim, Soung-Min (Department of Oral and Maxillofacial Surgery, College of Dentistry, Kangnung National University) ;
  • Kim, Ji-Hyuck (Department of Oral and Maxillofacial Surgery, College of Dentistry, Kangnung National University) ;
  • Park, Young-Wook (Department of Oral and Maxillofacial Surgery, College of Dentistry, Kangnung National University)
  • 발행 : 2007.02.28
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초록

The purpose of this study is to evaluate the regenerative capacity of reconstruction in the atrophied posterior maxilla by comparing bone graft procedures and alveolar distraction osteogenesis (ADO) techniques. We performed the autogenous iliac bone graft (AGB group, 5 specimens in 3 patients), and the combination (Mixed group, 3 specimens in 3 patients) of the autogenous and deproteinized bovine bone ($Bio-Oss^{(R)}$, Geistlich Co., Switzerland) as the ratio of 2:1 in the sinus floor elevation procedures. ADO procedures using $TRACK^{(R)}$ (KLS Martin Co., Germany) were also performed to augment vertical alveolar height in atrophied posterior maxilla (ADO group, 5 specimens in 4 patients). Newly generated bone tissues were obtained with the 2.0mm diameter trephine bur (3i Co., USA) during implant fixture installation after 5-7 months. Routine histolomorphological observation, immunodot blot assay for quantitative evaluation, and immunohistochemical staining with antibodies to MMP-1, -9, -10, TIMP-1, -2, and BMP-2, -4 were all carried out. Lamellar bone formation was well shown in all specimens and new bone formations of ADO group increased than those of other procedures. In immunohistochemical staining, the strong expression of BMP-2 was shown in all specimens, and immunodot blot assay showed that bone formation is accompanied by the good induction of factors associated with angiogenesis and appeared more increased amount of osteogenic and angiogenic factors in ADO group. ADO is the most effective technique for new bone formation compared to sinus floor elevation with autogenous or mixed bone graft in the atrophied posterior maxilla. In the quantitative immunodot blot assay, the regenerated bone after ADO showed more increased products of VEGF, BMP-2, PCNA and MMP-1 than those after the other procedures, and these findings were able to be confirmed by immunohistochemical stainings.

키워드

참고문헌

  1. Chiapasco M, Romeo E, Casentini P: Alveolar distraction osteogenesis vs. vertical guided bone regeneration for the correction of vertically deficient edentulous ridges: A 1-3-year prospective study on humans. Clin Oral Impl Rest 2004;15:82-95 https://doi.org/10.1111/j.1600-0501.2004.00982.x
  2. Saulacic N, Gandara-Vila P, Somoza-Martin M: Distraction osteogenesis of the alveolar ridge: a review of the literature. Med Oral 2004;9:321-327
  3. Tatum HJ: Maxillary and sinus implant reconstructions. Dent Clin North Am 1986;30:207-229
  4. Groeneveld EHJ, van den Bergh JPA, Holzmann P: Histomorphometrical analysis of bone formed in human maxillary sinus floor elevations grafted with OP-1 device, demineralized bone matrix of autogenous bone. Comparison with non-grafted sites in a series of case reports. Clin Oral Impl Res 1999;10:499-509 https://doi.org/10.1034/j.1600-0501.1999.100608.x
  5. Artzi Z, Nemcovsky CE, Dayan D: Bovine-HA spongiosa blocks and immediate implant placement in sinus augmentation procedures. Histopathological and histomorphometric observations on different histological stainings in 10 consecutive patients. Clin Oral Impl Res 2002;13:420-427 https://doi.org/10.1034/j.1600-0501.2002.130411.x
  6. Garg AK: Grafting materials in repair and restoration. In: Lynch SE, Genco RJ & Marx RE eds. Tissue engineering. 1st ed. Chicago, Quintessence Publishing Inc. 1999:83-101
  7. Jensen SS, Shulman LB, Block MS: Report of the sinus consensus conference of 1996. Int J Oral Maxillofac Implants 1998;13:11-45
  8. Kirsch A, Ackermann KL, Hurzeler MB: Sinus grafting with porous hydroxyapatite. In: Jensen OT. The sinus bone graft. 1st ed. Chicago, Quintessence Publishing Inc 1999:79-94
  9. Misch CE: Maxillary sinus augmentation for endosteal implants: Organized alternative treatment plans. Int J Oral Implantol 1987;4:49-58
  10. Misch CE, Dietsh F: Endosteal implants and iliac crest grafts to restore severely resorbed totally edentulous maxillae-a retrospective study. J Oral Implantol 1994;29:100-110
  11. Misch CE, Dietsh-Misch F, Misch CM: Extraoral autogenous donor bone grafts for endosteal implants. In: Misch CE. Contemporary implant dentistry. Chicago, C.V. Mosby. 1999:521-538
  12. Sailer HF: A new method of inserting endosseous implants in totally atrophic maxillae. J Craniomaxillofac Surg 1989;17:299-305 https://doi.org/10.1016/S1010-5182(89)80057-5
  13. Tulasne JF: Sinus grafting with calvarial bone. In: Jensen OT. The sinus bone graft. 1999. Chicago, Quintessence Publishing Inc 1999:107-116
  14. Norton MR, Odell EW, Thompson ID: Efficacy of bovine bone mineral for alveolar augmentation: a human histologic study. Clin Oral Impl Res 2003;14:775-783 https://doi.org/10.1046/j.0905-7161.2003.00952.x
  15. Kim SJ, Kim SM, Kim JH: Comparative histomorphologic study of regenerated bone for the dental implant placement in the atrophied posterior maxilla. J Kor Oral Maxillofac Surg 2005;31(Supple.1):134-135
  16. Kim SJ, Kim SM, Kim JH: Comparative histomorphologic study of the distracted bone and grafted autogenous bone in maxillary sinus for the recovery of atrophied posterior maxilla. J Kor Maxillofac Plast Reconstr Surg 2004;26(Supple. 1):147
  17. Boyne PJ, Herford AS: Distraction osteogenesis of the nasal and antral osseous floor to enhance alveolar height. J Oral Maxillofac Surg 2004;62:123-130 https://doi.org/10.1016/j.joms.2004.06.029
  18. Marucci DD, Yu Y, McTavish J: Matrix metalloproteinases and their inhibitors in bone remodeling following distraction osteogenesis of the sheep mandible. J Craniomaxillofac Surg 2002;30:208-212 https://doi.org/10.1054/jcms.2002.0289
  19. Bord S, Horner A, Hembry RM: Distribution of matrix metalloproteinases and their inhibitor, TIMP-1, in developing human osteophytic bone. J Anat 1997;191(Pt 1):39-48 https://doi.org/10.1046/j.1469-7580.1997.19110039.x
  20. Breckon JJ, Hembry RM, Reynolds JJ: Matrix metalloproteinases and TIMP-1 localization at sites of osteogenesis in the craniofacial region of the rabbit embryo. Anat Rec 1995;242:177-187 https://doi.org/10.1002/ar.1092420206
  21. Ishiguro N, Ito T, Kurokouchi K: mRNA expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in interface tissue around implants in loosening total hip arthroplasty. J Biomed Mater Res 1996;32:611-617 https://doi.org/10.1002/(SICI)1097-4636(199612)32:4<611::AID-JBM14>3.0.CO;2-G
  22. McTavish J, Marucci DD, Bonar SF: Does the sheep mandible relapse following lengthening by distraction osteogenesis? J Craniomaxillofac Surg 2000;28:251-257 https://doi.org/10.1054/jcms.2000.0153
  23. Rauch F, Lauzier D, Croteau S: Temporal and spatial expression of bone morphogenetic protein-2, -4, and -7 during distraction osteogenesis in rabbits. Bone 2000;27:453-459 https://doi.org/10.1016/S8756-3282(00)00337-9
  24. Eckardt H, Bundgaard KG, Christensen KS: Effects of locally applied vascular endothelial growth factor(VEGF) and VEGF-inhibitor to the rabbit tibia during distraction osteogenesis. J Orthop Res 2003;21:335-340 https://doi.org/10.1016/S0736-0266(02)00159-6
  25. Pacicca DM, Patel N, Lee C: Expression of angiogenic factors during distraction osteogenesis. Bone 2003;33:889-898 https://doi.org/10.1016/j.bone.2003.06.002
  26. Choi IH, Chung CY, Cho TJ: Angiogenesis and mineralization during distraction osteogenesis. J Korean Med Sci 2002;17:435-447 https://doi.org/10.3346/jkms.2002.17.4.435