Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Anti-hyperlipidemia Effect of Gyeongshingangjeehwan (GGEx) in High Fat induced Obese Male Micro-pigs

고지방식이 수컷 micro-pig에서 경신강지환(經身降脂丸) (GGEx)의 고지혈증 개선효과

  • Yang, Yoo-In (Department of Formula-ology, College of Oriental Medicine, Dongeui University) ;
  • Jung, Yang-Sam (Department of Formula-ology, College of Oriental Medicine, Dongeui University) ;
  • Lee, Hee-Young (Department of Formula-ology, College of Oriental Medicine, Dongeui University) ;
  • Rhee, Sang-Dal (Korea Research Institute of Chemical Technology) ;
  • Kim, Byoung-Chul (Gorye Oriental Medicine Clinic) ;
  • Kim, Jong-Hoon (Neungin Oriental Medicine Clinic) ;
  • Seok, Hoa-Jun (Bondiol Sujeong Oriental Medicine Clinic) ;
  • Yoo, Jae-Sang (Bonghwang Oriental Medicine Clinic) ;
  • Yoon, Ki-Hyeon (Department of Formula-ology, College of Oriental Medicine, Dongeui University) ;
  • Jo, Ju-Heum (Woosim Oriental Medicine Clinic) ;
  • Kim, Hoon (Department of Medical History, College of Oriental Medicine, Dongeui University) ;
  • Kim, Gyeong-Chul (Department of Diagnostics, College of Oriental Medicine, Dongeui University) ;
  • Shin, Soon-Shik (Department of Formula-ology, College of Oriental Medicine, Dongeui University)
  • 양유인 (동의대학교 한의과대학 방제학교실) ;
  • 정양삼 (동의대학교 한의과대학 방제학교실) ;
  • 이희영 (동의대학교 한의과대학 방제학교실) ;
  • 이상달 (한국화학연구원) ;
  • 김병출 (고려한의원) ;
  • 김종훈 (능인한의원) ;
  • 석화준 (본디올수정한의원) ;
  • 유재상 (봉황한의원) ;
  • 윤기현 (동의대학교 한의과대학 방제학교실) ;
  • 조주흠 (우심한의원) ;
  • 김훈 (동의대학교 한의과대학 의사학교실) ;
  • 김경철 (동의대학교 한의과대학 진단학교실) ;
  • 신순식 (동의대학교 한의과대학 방제학교실)
  • Published : 2006.12.30
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Abstract

Objectives : We evaluated anti-hyperlipidemia effect of Gyeongshinganjeehwan (GGEx) in high fat induced obese male micro-pigs. Methods : 7 month-old micro-pigs are fed with normal (n = 3) or high fat diet (n = 18) for 12 weeks. The pig revealed obesity in high fat diet were divided into 2 groups (n = 5 each) and vehicle (OMP) and Gyeongshingangjeehwan (GGEx, 616.7 mg/kg/day) were administrated for 1 month. We monitored the changes in body weight and measured plasma cholesterol, triglyceride, free fatty acid, GOT and, GPT after 1 month. The visceral fat were measured with computerized tomography and weights of various organs were measured after sacrifice. Results : 1. GGEx group had significantly reduced body weight gain than obese control group in statistics. 2. GGEx group didn't significantly differ from obese control group in blood total cholesterol, blood LDL-cholesterol, blood triglyceride. but it's data were similar to normal control group. 3. GGEx group had prominantly reduced visceral fat than obese control group in computerized tomography. 4. Blood GOT and GPT didn't differ from between groups. The organ weight were not significant different. And it is normal in size and colour of visceral organs. Conclusions : It is concluded that GGEx has anti-hyperlipidemia effect by improving visceral fat and access to security.

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