Journal of Mechanical Science and Technology

The Korean Society of Mechanical Engineers (대한기계학회)
권호 표지

Improvement of the Representative Volume Element Method for 3-D Scaffold Simulation

  • Cheng Lv-Sha (Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China) ;
  • Kang Hyun-Wook (Department of Mechanical Engineering, Pohang University of Science and Technology) ;
  • Cho Dong-Woo (Department of Mechanical Engineering, Pohang University of Science and Technology)
  • Published : 2006.10.01
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Abstract

Predicting the mechanical properties of the 3-D scaffold using finite element method (FEM) simulation is important to the practical application of tissue engineering. However, the porous structure of the scaffold complicates computer simulations, and calculating scaffold models at the pore level is time-consuming. In some cases, the demands of the procedure are too high for a computer to run the standard code. To address this problem, the representative volume element (RVE) theory was introduced, but studies on RVE modeling applied to the 3-D scaffold model have not been focused. In this paper, we propose an improved FEM-based RVE modeling strategy to better predict the mechanical properties of the scaffold prior to fabrication. To improve the precision of RVE modeling, we evaluated various RVE models of newly designed 3-D scaffolds using FEM simulation. The scaffolds were then constructed using microstereolithography technology, and their mechanical properties were measured for comparison.

Keywords

References

  1. Fang, Z. and Sun, Wei., 2005, 'Computer-aided Characterization for Effective Mechanical Properties of Porous Tissue Scaffold,' Computer-aided Design, Vol. 37,pp. 65-72 https://doi.org/10.1016/j.cad.2004.04.002
  2. Fang, Z. and Sun, Wei., 2005, 'Hornogeniza-tion of Heterogeneous Tissue Scaffold: a Comparison of Mechanics, Asymptotic Homogenization, and Finite Element Approach,' J. of Bionics and Biomechanics, Vol. 2, pp. 17-29 https://doi.org/10.1533/abbi.2004.0002
  3. Hollister, S. J., Maddox, R. D. and Taboas, 2002, 'Optimal Design and Fabrication of Scaffolds to Mimic Tissue Properties and Satisfy Biological Constraints,' Biomaterials, Vol. 23, pp.95-103 https://doi.org/10.1016/S0142-9612(02)00148-5
  4. Hollister, S. J. and Kikuchi, N., 2005, 'Homogenization Theory and Digital Imaging: A Basis for Studying the Mechanics and Design Principles of Bone Tissue,' Biotechnology and Bioengineering, Vol. 43, Issue 7, pp. 586-596 https://doi.org/10.1002/bit.260430708
  5. Hutmacher, D. W., 2000, 'Scaffolds in Tissue Engineering Bone and Cartilage,' Biomaterials, Vol. 21, pp. 29-43 https://doi.org/10.1016/S0142-9612(00)00121-6
  6. Ikuta, K. and Hirowatari, K., 1993, 'Real Three-dimensional Microfabrication Using Stereo Lithography and metal Molding. In: Proceedings of the IEEE International Workshop on Micro Electro Mechanical Systems (MEMS '93),' Fort Lauderdale, FL, 7-10 February 1993, pp. 42-47 https://doi.org/10.1109/MEMSYS.1993.296949
  7. Kang, H. -W., Lee, I. H., Cho, D. -W. and Yun, W. S., 2005, 'Development of Micro-bellows Actuator Using Micro-stereolithography Technology,' International Conference on Microand Nano-engineering 2005, 9D_01, Vienna, Austria, September 19-22
  8. Landers, R. and Mulhaupt, R., 2000, 'Desktop Manufacturing of Complex Objects, Prototypes & Biomedical Scaffolds by Means of Computerassisted Design Combined with Computer-guided 3D Plotting of Polymers & Reactive Oligomers,' Macrol Mater Eng., Vol. 282, pp. 17-21 https://doi.org/10.1002/1439-2054(20001001)282:1<17::AID-MAME17>3.0.CO;2-8
  9. Langer, R. and Joseph. P., 1993, 'Tissue Engineering,' Science, Vol. 260, pp.920-926 https://doi.org/10.1126/science.8493529
  10. Lee, I. H. and Cho, D. -W., 2002, 'Microstereo lithography Photo polymer Solidification Patterns for Various Laser Beam Exposure Conditions,' International Journal of Manufacturing and Technology, Vol. 22, pp.410-416
  11. Lee, S. J. and Kim, B., 2005, 'Development of Three-dimensional Scaffolds Using Micro-stereo lithography Technology,' The 8th Annual Meeting of Tissue Engineering Society International, Shanghai, China, No. 269, October 22-25
  12. Lee, S. J., Kang, H. -W., Kim, Y. G. and Cho, D. -W., 2005, 'Development of a Micro-bloodtyping System Using Micro-stereolithography,' Sensors and Materials, Vol. 17, No.3, pp. 113-123
  13. Liu, Y. and Abramson, S., 2003, 'Characterizing the Mechanical Properties of Poly- (Dte CaRbONate) Scaffold from the Finite Element Simulation of its Microtopology,' IEEE Conference, 22-23 March https://doi.org/10.1109/NEBC.2003.1216045
  14. Vacanti, J. P. and Langer, R., 1999, 'Tissue Engineering: the Design and Fabrication of Living Replacement Devices for Surgical Reconstruction and Transplantation,' Lancet., Vol. 354, pp. 32-34 https://doi.org/10.1016/S0140-6736(99)90247-7