Journal of Microbiology and Biotechnology

  • 제16권9호
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  • Pages.1405-1409
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  • 2006
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Breast Cancer Chemopreventive Activity of Polysaccharides from Starfish In Vitro

  • Nam Kyung-Soo (Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Kim Cheorl-Ho (National Research Laboratory for Glycobiology and Department of Biological Science, Sungkyunkwan University) ;
  • Shon Yun-Hee (Intractable Disease Research Center, Dongguk University)
  • 발행 : 2006.09.01
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초록

Polysaccharides from the starfish Asterina pectinifera were assessed in vitro for their chemopreventive potential in human breast cancer. The polysaccharides from A. pectinifera inhibited cell proliferation in the estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) human breast carcinoma cell lines. In addition, the polysaccharides were found to be an inhibitor of cytochrome P450 1A1-mediated ethoxyresorufin O-deethylase activity, and caused a dose-dependent inhibition of aromatase activity in microsomes isolated from a human placenta. There was a significant reduction in the ornithine decarboxylase activity to 30.7% of the control in the polysaccharide-treated MCF-7 breast cancer cells. Therefore, the polysaccharides from A. pectinifera merit further investigation with respect to breast cancer chemoprevention.

키워드

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