Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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Toxicity of Phenols to the Nematode Caenorhabditis elegans

Caenorhabditis elegans를 이용한 phenol류의 독성 연구

  • Jung Kang-Sik (Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University) ;
  • Hyun Sun-Hee (Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University) ;
  • Choung Se-Young (Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University)
  • 정강식 (경희대학교 약학대학 위생화학교실) ;
  • 현선희 (경희대학교 약학대학 위생화학교실) ;
  • 정세영 (경희대학교 약학대학 위생화학교실)
  • Published : 2006.09.01
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Abstract

Caenorhabditis elegans(C. elegans) is a free-living soil nematode that commonly used as a biological model and recently, much work has been done using C. elegans as a toxicity model. To evaluate the acute toxicity of phenols to C. elegans, worms were subsequently exposed to nine different xenobiotics. This study described lethal toxicity, reproductive toxicity and movement inhibition using 2-propylphenol, 4-propylphenol, 2-tert-butylphenol, 3-tert-butylphenol, 4-tert-butylphenol, 2-phenylphenol, 4-phenylphenol, nonylphenol and 4-dodecylphenol to C. elegans for 24 hr or 72 hr. We found that phenols used in this study were very toxic to C. elegans. The order of lethal toxicity, reproductive toxicity and movement inhibition is as follows. 4-propylphenol > 2-phenylphenol > 2-tert-butylphenol > 2-propylphenol > nonylphenol > B-tert-butylphenol > 4-dodefylphenol > 4-tert-butylphenol > 4-phenylphenol.

Keywords

References

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