Journal of the Korean Statistical Society

The Korean Statistical Society (한국통계학회)
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ASSESSING POPULATION BIOEQUIVALENCE IN A $2{\times}2$ CROSSOVER DESIGN WITH CARRYOVER EFFECT IN A BAYESIAN PERSPECTIVE

  • Oh Hyun-Sook (Department of Applied Statistics, Kyungwon University)
  • Published : 2006.09.01
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Abstract

A $2{\times}2$ crossover design including carryover effect is considered for assessment of population bioequivalence of two drug formulations in a Bayesian framework. In classical analysis, it is complex to deal with the carryover effect since the estimate of the drug effect is biased in the presence of a carryover effect. The proposed method in this article uses uninformative priors and vague proper priors for objectiveness of priors and the posterior probability distribution of the parameters of interest is derived with given priors. The posterior probabilities of the hypotheses for assessing population bioequivalence are evaluated based on a Markov chain Monte Carlo simulation method. An example with real data set is given for illustration.

Keywords

References

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