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Fabrication of Functionally Gradient Porous Al2O3-(t-ZrO2)/HAp Composites and their In-Vitro Study

조성 경사구조를 갖는 다공질 Al2O3-(t-ZrO2)/HAp 복합체의 제조 및 In-Vitro 실험

  • Kim, Ki-Ho (School of Advanced Materials Engineering, Engineering College, Kongju National University) ;
  • Kim, Young-Hee (Department of Microbiology, School of Medicine, Soonchunhyang University) ;
  • Song, Ho-Yeon (Department of Microbiology, School of Medicine, Soonchunhyang University) ;
  • Lee, Byong-Taek (School of Advanced Materials Engineering, Engineering College, Kongju National University)
  • 김기호 (공주대학교 신소재공학부) ;
  • 김영희 (순천향대학교 의과대학 미생물학교실) ;
  • 송호연 (순천향대학교 의과대학 미생물학교실) ;
  • 이병택 (공주대학교 신소재공학부)
  • Published : 2006.08.01

Abstract

Functionally gradient porous $Al_2O_3-(t-ZrO_2)/HAp$ composites consist of 3 layers were fabricated using the multi-pass extrusion process at the various temperatures. The continuous pores were homogeneously formed in the $2^{nd}$ passed samples and their size was about $180{\mu}m$ in diameter. In the porous composites sintered at $1200-1400^{\circ}C$, the relative density and bending strength increased with the sintering temperature. The maximum values of relative density and bending strength in the $2^{nd}$ passed $Al_2O_3-(t-ZrO_2)/HAp$ composites were 62.2% and 107.8 MPa, respectively. In order to investigate the growth behavior of osteogenic cells on the functionally gradient porous $Al_2O_3-(t-ZrO_2)/HAp$ composites, an in vitro test was performed, using human osteoblast-like MG-63 cells. The cells were well attached and grown on the rough surface of the inside of the functionally gradient porous body.

Keywords

References

  1. B. T. Lee, K. H. Kim, and J. K. Han, 'Microstructures and Material Properties of Fibrous $Al_2O_3-(m-ZrO_2)/t-ZrO_2$ Composites Fabricated by a Fibrous Monolithic Process,' J. Mater. Res., 19 3234-41 (2004) https://doi.org/10.1557/JMR.2044.0414
  2. B. T. Lee, D. H. Jang, I. C. Kang, and C. W. Lee, 'Relationship between Microstructures and Material Properties of Novel Fibrous $Al_2O_3-(m-ZrO_2)/t-ZrO_2$ Composites,' J. Am. Ceram. Soc., 88 2874-78 (2005) https://doi.org/10.1111/j.1551-2916.2005.00519.x
  3. K. A. Hing, S. M. Best, and W. Bonfield, 'Characteristic of Porous Hydroxyapatite,' J. Mater. Sci.: Mater. in Med., 10 135-45 (1999) https://doi.org/10.1023/A:1008929305897
  4. M. Fabbri, G. C. Celotti, and A. Ravaglioli, 'Hydroxyapatite- Based Porous Aggregates: Physico-Chemical Nature, Structure, Texture, and Architecture,' Biomaterials, 16 225- 28 (1995) https://doi.org/10.1016/0142-9612(95)92121-L
  5. W. Xue, S. Tao, X. Liu, X. Zheng, and C. Ding, 'In Vivo Evaluation of Plasma Sprayed Hydroxyapatite Coating having Different Crystallinity,' Biomaterials, 25 415-21 (2004) https://doi.org/10.1016/S0142-9612(03)00545-3
  6. Y. K. Jun, W. H. Kim, O. K. Kweon, and S. H. Hong, 'The Fabrication and Biochemical Evaluation of Alumina Reinforced Calcium Phosphate Porous Implants,' Biomaterials, 24 3731-39 (2003) https://doi.org/10.1016/S0142-9612(03)00248-5
  7. V. S. Komlev, S. M. Barinov, and E. V. Koplik, 'A Method to Fabricate Porous Spherical Hydroxyapatite Granules Intended for Time-Controlled Drug Release,' Biomaterials, 23 3449-54 (2002) https://doi.org/10.1016/S0142-9612(02)00049-2
  8. M. H. Youn, R. K. Paul, H. Y. Song, and B. T. Lee, 'Fabrication of Porous Structure of BCP Sintered Bodies Using Microwave Assisted Synthesized HAp Nano Powder,' Key Engineering, In press
  9. F. Chen, Z. C. Wang, and C. J. Lin, 'Preparation and Characterization of Nano-Sized Hydroxyapatite Particles and Hydroxyapatite/Chitosan Nano-Composite for Use in Biomedical Materials,' Mater. Lett., 57 858-61 (2002) https://doi.org/10.1016/S0167-577X(02)00885-6
  10. A. R. Kmita, A. Slosarczhk, Z. Paszkiewicz, and C. Paluszkiewicz, 'Phase Stability of Hydrxyapatite-$ZrO_2 (HAp- ZrO_2)$ Composites for the Bone Replacement,' J. Mole. Struct., 704 333-40 (2004) https://doi.org/10.1016/j.molstruc.2004.02.047
  11. A. R. Kmita, A. Slosarczhk, and Z. Paszkiewicz, 'Mechanical Properties of HAp-$ZrO_2$ Composites,' J. Eur. Ceram. Soc., 26 1481-88 (2006) https://doi.org/10.1016/j.jeurceramsoc.2005.01.059
  12. Y. M. Sung and D. H. Kim, 'Crystallization Characteristics of Yttria-Stabilizedzirconia/Hydroxyapatite Composite Nanopowder,' J. Crystal. Growth, 254 411-17 (2003) https://doi.org/10.1016/S0022-0248(03)01191-6
  13. A. K. Gain and B. T. Lee, 'Fabrication of HAp-Coated Micro-Channelled t-$ZrO_2$ Bodies by the Multi-Pass Extrusion Process,' J. Am. Ceram. Soc., 89 [6] 2051-56 (2006) https://doi.org/10.1111/j.1551-2916.2006.01032.x
  14. B. T. Lee, I. C. Kang, S. H. Cho, and H. Y. Song, 'Fabrication of Continuously Oriented Porous $Al_2O_3$ Body and Its In-Vitro Study,' J. Am. Ceram. Soc., 88 [8] 2262-66 (2005) https://doi.org/10.1111/j.1551-2916.2005.00364.x