Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Magnetic Resonance Imaging in 24 Dogs with Chiari type 1-like Malformations

자기공명영상을 이용한 24마리의 개에서의 Chiari 1형 유사 기형 진단

  • Choi Ho-Jung (College of Veterinary Medicine, Chungnam National University) ;
  • Lee Young-Won (College of Veterinary Medicine, Chungnam National University)
  • Published : 2006.06.01
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Abstract

Chiari type 1 malformation is a developmental condition characterized by cerebellar herniation and syringohydromyelia in human beings. It has been reported as a common condition in the cavalier King Charles spaniel that is similar to human Chiari type 1 malformations. However, there are few documentations of diagnosed Chiari type 1 like malformation in other breed dogs. Abnormalities compatible with such a malformation were identified by magnetic resonance imaging in 24 dogs with neurologic signs in this study. The dogs were 15 females and 9 males. Their breed were variable, and 6 of the dogs were maltese, 5 were shih-tzu. The dogs had a variety of neurological signs and the severity of cerebellar herniation, syringohydromyelia, intracranial intra-arachnoid cyst or hydrocephalus.

사람에서, Chiari 1형 기형은 소뇌 탈출과 척수공동증이 특정인 발달성 장애이다. 이러한 사람의 Chiari 1형 기형과 유사한 질환이 cavalier King Charles spaniels에서 흔히 나타났다. 그러나, 이러한 Chiari 1형 유사 기형이 다른 종의 개에서 진단 보고된 증례가 거의 없는 실정이다. 이에 본 연구에서는 24 마리의 개에서 자기공명영상 장치를 이용하여 Chiari 1형 유사 기형으로 진단된 증례를 보고하고자 한다. 이 개들은 다양한 신경 증상과 다양한 정도의 소뇌 탈출, 척수공동증, 두개관내 거미막 낭종 또는 뇌수종의 병발 질환들을 나타내었다.

Keywords

References

  1. Aboulezz AO, Sartor K, Geyer CA, Gado MH. Position of cerebellar tonsils with Chiari malformation: A quantitative approach with MR imaging. J Comput Assist Tomogr 1985; 9: 1033-1036 https://doi.org/10.1097/00004728-198511000-00005
  2. Ball WS Jr, Crone KR. Chiari I malformation: from Dr Chiari to MR imaging. Radiology 1995; 195: 602-604 https://doi.org/10.1148/radiology.195.3.7753980
  3. Bynevelt M, Rusbridge C, Britton J. Dorsal dens angulation and a Chiari type I malformation in a Cavalier King Charles Spaniel. Vet Radiol Ultrasound 2000; 41: 521-524 https://doi.org/10.1111/j.1740-8261.2000.tb01882.x
  4. Cai C, Oakes WJ. Hindbrain herniation syndromes: the Chiari malformation (I and II). Seminars in Pediatric Neurology 1997; 4: 179-191 https://doi.org/10.1016/S1071-9091(97)80036-8
  5. Churcher RK, Child G. Chiari 1/syringomyelia complex in a King Charles Spaniel. Aus Vet J 2000; 78: 92-95 https://doi.org/10.1111/j.1751-0813.2000.tb10530.x
  6. Dewey CW. Myelopathies: Disorders of the spinal cord. In: A practical guide to canine and feline neurology, Ames: Blackwell. 2003: 310-312
  7. Elia M, Biondi R, Sofia V, Musumeci SA, Ferri R, Capovilla G, Curatolo P. Seizures in Chiari I malformation: a clinical and electroencephalographic study. J Child Neuro 1999; 14: 446-450 https://doi.org/10.1177/088307389901400707
  8. Kirberger RM, Jacobsen LS, Davies JV, Engela J. Hydromyelia in the dog. Vet Radiol & Ultrasound 1997; 38: 30-38 https://doi.org/10.1111/j.1740-8261.1997.tb01599.x
  9. Lee BCP, Zimmerman RD, manning JJ, Deck MDF. MR imaging of syringomyelia and hydromyelia. AJNR 1985; 6: 221-228
  10. Lu D, Lamb CR, Pfeiffer DU, Targett MP. Neurological signs and results of magnetic resonance imaging in 40 cavalier King Charles spaniels with Chiari type I-like malformations. Vet Rec 2003; 153: 260-263 https://doi.org/10.1136/vr.153.9.260
  11. Meadows J, Krait M, Guarnieri M, Haroun RI, Carson BS. Asymptomatic Chiari type I malformations identified on magnetic resonance imaging. J Neurosurg 2000; 92: 920-926 https://doi.org/10.3171/jns.2000.92.6.0920
  12. Menezes AH. Chiari I malformations and hydromyelia-complications. Pediatr Neurosurg 1991; 17: 146-154 https://doi.org/10.1159/000120586
  13. Milhorat TH, Chou MW, Trinidaa EM, Kula RW, Mandell M, Wolpert C, Speer MC. Chiari I malformation redefined: clinical and radiographic findings for 364 symptomatic patients. Neurosurg 1999; 44: 1005-1017 https://doi.org/10.1097/00006123-199905000-00042
  14. Nishikawa M, Sakamoto H, Hakuba A, Nakanishi N, Inoue Y. Pathogenesis of Chiari malformation: a morphometric study of the posterior cranoal fossa. J Neurosurg 1997; 86: 40-47 https://doi.org/10.3171/jns.1997.86.1.0040
  15. Oldfield EH, Muraszko K, Shawker TH, Patronas NJ. Pathophysiology of syringomyelia associated with Chiari I malformation of the cerebellar tonsils. Implications for diagnosis and treatment. J Neurosurg 1994; 80: 3-15 https://doi.org/10.3171/jns.1994.80.1.0003
  16. Paul KS, Lye RH, Strang FA, Dutton J. Arnold-Chiari malformation. J Neurosurg 1983; 58: 183-187 https://doi.org/10.3171/jns.1983.58.2.0183
  17. Platt SR. Neck and back pain. In: BSAVA manual of canine and feline neurology, 3rd ed. Dorset: BSAVA. 2004: 202-207
  18. Rusbridge C, Macsweeney JE, Davies JV, Chandler K, Fitzmaurice SN, Dennis R, Cappello R, Wheeler SJ. Syringo-hydromyelia in Cavalier King Charles Spaniels. J Neurol Sci 2000; 82: 193-201 https://doi.org/10.1016/0022-510X(87)90018-9
  19. Rusbridge C, Knowler SP. Hereditary aspects of occipital bone hypoplasia and syringomyelia (Chiari type I malformation) in cavalier King Charles spaniels. Vet Rec 2003; 153: 107-112 https://doi.org/10.1136/vr.153.4.107
  20. Rusbridge C, Knowler SP. Syringohydromyelia secondary to occipital bone hypoplasia (Chiari malformation) in cavalier King Charles spaniels. J Vet Intern Med 2004; 18: 673-678 https://doi.org/10.1892/0891-6640(2004)18<673:IOOBHC>2.0.CO;2
  21. Schady W, Metcalfe RA, Butler P. The incidence of craniocervical bony abnormalities in the Chiari malformation. J Neurol Sci 1987; 82: 193-201 https://doi.org/10.1016/0022-510X(87)90018-9
  22. Tanghe HLJ. Magnetic resonance imaging (MRI) in syringomyelia. Acta Neurochirurgica 1995; 134: 93-99 https://doi.org/10.1007/BF01428512