The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Water Extract of Sobokchuko-tang on Rat Blood Vessels

소복축어탕(小腹逐瘀湯)이 흰쥐 흉부대동맥의 혈관운동성에 미치는 영향

  • Jung, Yong-Sik (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Kwon, Jung-Nam (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Min, Sung-Soon (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Kim, Jong-Deuk (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Lee, Sang-Hee (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Kim, Jae-Kyu (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Heo, Jeong-Eun (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Kim, Young-Kyun (Department of Circulatory Internal Medicine, College of Oriental Medicine, Dong-Eui University)
  • 정용식 (동의대학교 부속한방병원 심계내과학 교실) ;
  • 권정남 (동의대학교 부속한방병원 심계내과학 교실) ;
  • 민성순 (동의대학교 부속한방병원 심계내과학 교실) ;
  • 김종득 (동의대학교 부속한방병원 심계내과학 교실) ;
  • 이상희 (동의대학교 부속한방병원 심계내과학 교실) ;
  • 김재규 (동의대학교 부속한방병원 심계내과학 교실) ;
  • 허정은 (동의대학교 부속한방병원 심계내과학 교실) ;
  • 김영균 (동의대학교 부속한방병원 심계내과학 교실)
  • Published : 2006.09.30
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Abstract

This study was carried out to examine the relaxational response to the water extract of Sobokchuko-tang (SCT) in rat thoracic aorta. Segments of thoracic aorta obtained from rats immediately after delivery were mounted in organ baths superfused on a polygraph. It was found that the thoracic aorta segments responded to the SCT with dose-dependent vasorelaxation. At $10^{-7}M$ phenylephrine-induced contraction, the contractile response of thoracic aortic rings were inhibited by 99.2%. 75.3%. 42.4% and 35.8% after addition of the respective concentration (1O. 30. 100. $300{\mu}g$/ml) of SCT. This vasorelaxation of rat thoracic aorta was endothelium-dependent. The action mechanisms of vasorelaxation are thought to be concerned with the role of NO. cAMP and cyclooxygenase. but not with cGMP.

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