Mycobacterium Kansasii Disease Presenting As a Lung Mass and Bronchial Anthracofibrosis

폐종괴와 기관지 탄분섬유화로 발현한 Mycobacterium kansasii 감염 1 예

  • Ra, Seung Won (Division of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Lee, Kwang Ha (Division of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Jung, Ju Young (Division of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kang, Ho Suk (Division of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Park, I Nae (Division of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Choi, Hye Sook (Division of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Jung, Hoon (Division of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Chon, Gyu Rak (Division of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Shim, Tae Sun (Division of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center)
  • 나승원 (울산대학교 의과대학 서울아산병원 호흡기내과) ;
  • 이광하 (울산대학교 의과대학 서울아산병원 호흡기내과) ;
  • 정주영 (울산대학교 의과대학 서울아산병원 호흡기내과) ;
  • 강호석 (울산대학교 의과대학 서울아산병원 호흡기내과) ;
  • 박이내 (울산대학교 의과대학 서울아산병원 호흡기내과) ;
  • 최혜숙 (울산대학교 의과대학 서울아산병원 호흡기내과) ;
  • 정훈 (울산대학교 의과대학 서울아산병원 호흡기내과) ;
  • 전규락 (울산대학교 의과대학 서울아산병원 호흡기내과) ;
  • 심태선 (울산대학교 의과대학 서울아산병원 호흡기내과)
  • Received : 2006.01.23
  • Accepted : 2006.04.19
  • Published : 2006.04.30

Abstract

The incidence of Mycobacterium kansasii pulmonary diseases are on the increase in Korea with the higher probability of occurrence in middle-aged and older men with underlying lung diseases Among nontuberculosus mycobacterial (NTM) infections, the clinical features of M. kansasii pulmonary infection are most similar to those of tuberculosis (TB). The chest radiographic findings of M. kansasii infection are almost indistinguishable from those of M. tuberculosis (predominance of an upper lobe infiltration and cavitary lesions), even though some suggest that cavities are more commonly thin-walled and have less surrounding infiltration than those of typical TB lesions. Although there are reports on the rare manifestations of M. kansasii infections, such as endobronchial ulcer, arthritis, empyema, cutaneous and mediastinal lymphadenitis, cellulites and osteomyelitis, the association with bronchial anthracofibrosis has not yet been reported. This report describes the first case of M. kansasii infection presenting as a lung mass in the right lower lobe with accompanying bronchial anthracofibrosis.

폐종괴로 발현하는 M. kansasii 감염은 흔하지 않으며 기관지 탄분섬유화증을 동반한 M. kansasii 폐감염에 대한 보고는 아직 없었다. 기저질환 없이 면역력이 정상인 비흡연자에서 우하엽의 폐종괴로 발현하고 기관지 탄분섬유화증을 동반한 M. kansasii 폐감염에 대하여 표준 치료로 호전되고 있는 증례를 경험하였기에 보고하는 바이다.

Keywords

References

  1. American Thoracic Society. Diagnosis and treatment of disease caused by nontuberculous mycobacteria. Am J Respir Crit Care Med 1997;156:S1-25 https://doi.org/10.1164/ajrccm.156.2.atsstatement
  2. Yim JJ, Park YK, Lew WJ, Bai GH, Han SK, Shim YS. Mycobacterium kansasii pulmonary diseases in Korea. J Korean Med Sci 2005;20:957-60 https://doi.org/10.3346/jkms.2005.20.6.957
  3. Griffith DE. Management of disease due to Mycobacterium kansasii. Clin Chest Med 2002;23: 613-21 https://doi.org/10.1016/S0272-5231(02)00016-3
  4. Koh WJ, Kwon OJ, Suh GY, Chung MP, Kim HJ, Lee NY, et al. A case report of three patients with nontuberculous mycobacterial pulmonary disease caused byMycobacterium kansasii. Tuberc Respir Dis 2003; 54:459-66 https://doi.org/10.4046/trd.2003.54.4.459
  5. Scientific Committee in Korean Academy of Tuberculosis and Respiratory Diseases. National survey of mycobacterial diseases other than tuberculosis in Korea. Tuberc Respir Dis 1995;42:277-94 https://doi.org/10.4046/trd.1995.42.3.277
  6. Maliwan N, Zvetina JR. Clinical features and follow up of 302 patients with Mycobacterium kansasii pulmonary infection: a 50 year experience. Postgrad Med J 2005;81:530-3 https://doi.org/10.1136/pgmj.2004.026229
  7. Aberg JA, Yajko DM, Jacobson MA. Eradication of AIDS-related disseminated Mycobacterium avium complex infection after 12 months of antimycobacterial therapy combined with highly active antiretroviral therapy. J Infect Dis 1998;178:1446-9 https://doi.org/10.1086/314469
  8. Prince DS, Peterson DD, Steiner RM, Gottlieb JE, Scott R, Israel HL, et al. Infection withMycobacterium avium complex in patients without predisposing conditions. N Engl J Med 1989;321:863-8 https://doi.org/10.1056/NEJM198909283211304
  9. Park SY, Park JH, Jegal YJ, Lee JH, Lim CM, Lee SD, et al. Acase of idiopathic CD4+T-lymphocytopenia with disseminated Mycobacterium kansasii infection and pulmonary alvelolar proteinosis. Tuberc Respir Dis 2000;48:377-82 https://doi.org/10.4046/trd.2000.48.3.377
  10. Bloch KC, Zwerling L, Pletcher MJ, Hahn JA, Gerberding JL, Ostroff SM, et al. Incidence and clinical implications of isolation of Mycobacterium kansasii: results of a 5-year, population-based study. Ann Intern Med 1998;129:698-704 https://doi.org/10.7326/0003-4819-129-9-199811010-00004
  11. Corbett EL, Blumberg L, Churchyard GJ, Moloi N, Mallory K, Clayton T, et al. Nontuberculous mycobacteria: defining disease in a prospective cohort of South African miners. Am J Respir Crit Care Med 1999;160:15-21 https://doi.org/10.1164/ajrccm.160.1.9812080
  12. Ahn CH, Lowell JR, Ahn SS, Ahn S, Hurst GA. Chemotherapy for pulmonary disease due to Mycobacterium kansasii: efficacies of some individual drugs. Rev Infect Dis 1981;3:1028–34
  13. Witzig RS, Fazal BA, Mera RM, Mushatt DM, Dejace PM, Greer DL, et al. Clinical manifestations and implications of coinfection withMycobacterium kansasii and human immunodeficiency virus type 1. Clin Infect Dis 1995;21:77-85 https://doi.org/10.1093/clinids/21.1.77
  14. Manali ED, Tomford WJ, Liao DW, Farver C, Mehta AC. Mycobacterium kansasii endobronchial ulcer in a nonimmunocompromised patient. Respiration 2005; 72:305-8 https://doi.org/10.1159/000085373