A Case of Alpha-Fetoprotein Producing Adenocarcinoma of the Lung

알파태아단백을 분비하는 원발성 폐 선암 1예

  • No, Eun-Ji (Department of Internal Medicine, Pusan Paik Hospital, Inje University) ;
  • Hur, Jin-Won (Department of Internal Medicine, Pusan Paik Hospital, Inje University) ;
  • Lee, Sung Soon (Department of Internal Medicine, Pusan Paik Hospital, Inje University) ;
  • Lee, Young Min (Department of Internal Medicine, Pusan Paik Hospital, Inje University) ;
  • Lee, Hyuk Pyo (Department of Internal Medicine, Pusan Paik Hospital, Inje University) ;
  • Kim, Joo In (Department of Internal Medicine, Pusan Paik Hospital, Inje University) ;
  • Yum, Ho-Kee (Department of Internal Medicine, Pusan Paik Hospital, Inje University) ;
  • Choi, Soo Jeon (Department of Internal Medicine, Pusan Paik Hospital, Inje University) ;
  • Choi, Suk-Jin (Department of Radiology, Pusan Paik Hospital, Inje University) ;
  • Kim, Chan-Hwan (Department of Pathology, Pusan Paik Hospital, Inje University) ;
  • Lee, Hyun-Kyung (Department of Internal Medicine, Pusan Paik Hospital, Inje University)
  • 노은지 (인제대학교 의과대학 내과학교실) ;
  • 허진원 (인제대학교 의과대학 내과학교실) ;
  • 이성순 (인제대학교 의과대학 내과학교실) ;
  • 이영민 (인제대학교 의과대학 내과학교실) ;
  • 이혁표 (인제대학교 의과대학 내과학교실) ;
  • 김주인 (인제대학교 의과대학 내과학교실) ;
  • 염호기 (인제대학교 의과대학 내과학교실) ;
  • 최수전 (인제대학교 의과대학 내과학교실) ;
  • 최석진 (인제대학교 의과대학 영상의학교실) ;
  • 김찬환 (인제대학교 의과대학 진단병리학교실) ;
  • 이현경 (인제대학교 의과대학 내과학교실)
  • Received : 2006.04.24
  • Accepted : 2006.06.14
  • Published : 2006.07.30

Abstract

Alpha-fetoprotein(AFP) is a plasma protein produced in the fetal liver, yolk sac and gastrointestinal tract. The plasma level of AFP decreases markedly 1 year after birth. The AFP level is usually increased in hepatocellular carcinoma and yolk sac tumor but is rare in a primary lung cancer. We report a case of primary adenocarcinoma of lung producing high levels of AFP.

우상엽 종괴에 대한 검사 중, 폐암 특히 선암의 암세포 표지인자인 CEA가 증가 되어 있으면서, 간암 및 생식세포 종양의 표지인자인 AFP가 매우 증가되어 있는 원발성 폐암으로 진단된 환자를 경험하여 보고한다.

Keywords

References

  1. Gitlin D, Pericelli A, Gitlin GM. Synthesis of alphafetoprotein by liver, york sac, and gastrointestinal tract of the human conceptus. Cancer Res 1972;32: 979-82
  2. Ruoslahti E, Seppala M. Alpha-fetoprotein in cancer and fetal development. Adv Cancer Res 1979;29: 275-346 https://doi.org/10.1016/S0065-230X(08)60849-0
  3. Javaspour N. The National Cancer Institute experience with testicular cancer. J Urol 1978;120:651-9 https://doi.org/10.1016/S0022-5347(17)57316-4
  4. Kato K, Akai S, Tobia Y, Tsutsui K, Tsunoda H, Suzuki M. Alpha fetoprotein positive cases in cancer except for hepatoma and malignant teratoma: mainly on the sum up data in Japan. Jpn J Cancer Clin 1974;20:376-82
  5. Holyoke ED, Chu TM, Murphy GP. CEA as a monitor of gastrointestinal malignancy. Cancer 1975;35:830-6 https://doi.org/10.1002/1097-0142(197503)35:3<830::AID-CNCR2820350340>3.0.CO;2-H
  6. Spragins J, Hall WH, White HJ. Fetoprotein from esophageal squamous cell carcinoma. Ann Intern Med 1972;77;322-3
  7. Mostofi FK. Pathology of germ cell tumors of testis. Cancer 1980;45(Suppl):I735-54
  8. O'concor GT, Tatarinov YS, Abelev GI, Uriel J. A collaborative study for the evaluation of serologic test for primary liver cancer. Cancer 1970;25:1091-8 https://doi.org/10.1002/1097-0142(197005)25:5<1091::AID-CNCR2820250514>3.0.CO;2-P
  9. McIntire KR, Waldmann TA, Moertel CG, Go VL. Serum alpha-fetoprotein in patients with neoplasms of the gastrointestinal tract. Cancer Res 1975;35: 991-6
  10. Masopust J, Kithier K, Radl J, Kouteeky J, Kotal L. Occurrence of fetoprotein in patients with neoplasm and non-neoplastic disease. Int J Cancer 1968;3: 364-73 https://doi.org/10.1002/ijc.2910030306
  11. Kozower M, Fawaz KA, Miller HM, Kaplan M. Positive alpha fetoglobulin in a case of gastric carcinoma. N Engl J Med 1971;285:1059-60 https://doi.org/10.1056/NEJM197111042851906
  12. Yasunami R, Hashimoto Z, Ogura T, Hirao F, Yamamura Y. Primary lung cancer producing alphafetoprotein. Cancer 1981;47:926-9 https://doi.org/10.1002/1097-0142(19810301)47:5<926::AID-CNCR2820470518>3.0.CO;2-O
  13. Miyake M, Ito M, Mitsuoka A, Taki T, Wada H, Hitomi S, et al. Alpha-fetoprotein and human chorionic gonadotropin producing lung cancer. Cancer 1987;59:227-32. https://doi.org/10.1002/1097-0142(19870115)59:2<227::AID-CNCR2820590209>3.0.CO;2-X
  14. Asamura H, Nakayama H, Kondo H, Tsuchiya R, Ono R, Noguchi M, et al. AFP-producing squamous cell carcinoma of the lung in adolescent. Jpn J Clin Oncol 1996;26:103-6 https://doi.org/10.1093/oxfordjournals.jjco.a023181