Asian-Australasian Journal of Animal Sciences

  • 제19권8호
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  • Pages.1090-1094
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  • 2006
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Global Histone H4 Acetylation of IGF1 and GH Genes in Lungs of Somatic Cell Cloned Calves

  • Zhang, L. (National Laboratory for Agrobiotechnology, China Agricultural University) ;
  • Wang, S.H. (National Laboratory for Agrobiotechnology, China Agricultural University) ;
  • Fan, B.L. (National Laboratory for Agrobiotechnology, China Agricultural University) ;
  • Dai, Y.P. (National Laboratory for Agrobiotechnology, China Agricultural University) ;
  • Fei, J. (National Laboratory for Agrobiotechnology, China Agricultural University) ;
  • Li, N. (National Laboratory for Agrobiotechnology, China Agricultural University)
  • 투고 : 2005.09.12
  • 심사 : 2006.03.08
  • 발행 : 2006.08.01
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초록

Histone acetylation modification is one key mechanism in the regulation of gene activation. In this study, we investigated the global levels of histone H4 acetylation of insulin like growth factor I (IGF1) and growth hormone (GH) genes in the lungs of two somatic cell cloned calves. Data showed the levels of histone H4 acetylation of IGF1 and GH genes vary widely within different gene regions, and, in almost all regions of the two genes, acetylation levels are lower in the aberrant clone than in the normal clone. Thus we suggest that inefficient epigenetic reprogramming in the clone may affect the balance between acetylation and deacetylation, which will affect normal growth and development. These findings will also have implications for improvement of cloning success rates.

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참고문헌

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