Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Bickerstaff's Brainstem Encephalitis Treated with Immunoglobulin

면역글로불린으로 치료한 Bickerstaff 뇌간뇌염 1예

  • Kim, Beom Joon (Department of Neurology, Seoul National University College of Medicine) ;
  • Choi, Yoon Jae (Department of Neurology, Seoul National University College of Medicine) ;
  • Kim, Nam-Hee (Department of Neurology, Dongguk University International Hospital) ;
  • Hong, Yoon-Ho (Department of Neurology, Seoul National University College of Medicine) ;
  • Sung, Jung-Joon (Department of Neurology, Seoul National University College of Medicine) ;
  • Han, Moon-Ku (Department of Neurology, Seoul National University College of Medicine) ;
  • Park, Seong-Ho (Department of Neurology, Seoul National University College of Medicine) ;
  • Lee, Kwang-Woo (Department of Neurology, Seoul National University College of Medicine) ;
  • Park, Kyung Seok (Department of Neurology, Seoul National University College of Medicine)
  • 김범준 (서울대학교 의과대학 신경과학교실) ;
  • 최윤재 (서울대학교 의과대학 신경과학교실) ;
  • 김남희 (일산동국대학교병원 신경과) ;
  • 홍윤호 (서울대학교 의과대학 신경과학교실) ;
  • 성정준 (서울대학교 의과대학 신경과학교실) ;
  • 한문구 (서울대학교 의과대학 신경과학교실) ;
  • 박성호 (서울대학교 의과대학 신경과학교실) ;
  • 이광우 (서울대학교 의과대학 신경과학교실) ;
  • 박경석 (서울대학교 의과대학 신경과학교실)
  • Published : 2006.06.30
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Abstract

Bickerstaff's brainstem encephalitis (BBE) is a rare disorder with acute ophthalmoparesis, ataxia, consciousness disturbance, and pyramidal signs of suspected autoimmune origin. A-62-year-old woman developed acute diplopia, dysarthria, gaze-paretic nystagmus and gait ataxia. Her mental status fell subsequently into stupor. Brain MRI and nerve conduction study showed no significantly abnormal findings. Electroencephalography revealed diffuse low voltage slowings. After treating with intravenous immunoglobulin, she demonstrated rapid clinical recovery. This case suggests that immunoglobulin can be an alternative option in BBE treatment, especially when plasmapheresis and corticosteroids are difficult or contraindicated.

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