Acute Parkinsonism with Bilateral Basal Ganglia Lesions in A Patient with Uremia

요독증 환자의 양측 기저핵 병변에 의해 발생된 급성 파킨슨증 1예

A 47-year-old male who had hypertension and diabetes mellitus for 7 years suddenly developed bradykinesia, generalized limb muscular rigidity, dysarthria and dysphagia. Uremia developed 5 months prior to this and he had been on hemodialysis. A T2-weighted brain MRI showed extensive hyperintensity over the bilateral basal ganglia, extending to the adjacent periventricular white matter. In T1-weighted images the lesions were hypointense. Supportive treatments were given and his symptoms improved. Exacerbation of glucose utilization failure or vasogenic edema is suggested as the etiology of basal ganglia lesions, but the exact underlying pathophysiology is unknown.