Journal of Microbiology and Biotechnology

  • 제16권5호
  • /
  • Pages.817-820
  • /
  • 2006
  • /
  • 1017-7825(pISSN)
  • /
  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Evaluation of Genotoxicity on Plant-Derived Dietary Sulfur

  • 발행 : 2006.05.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The potential genotoxicity of methylsulfonylmethane, a crystalline organic sulfur, derived from chemically modified lignin from plants was evaluated using in vitro and in vivo assays. In the bacterial reverse mutation test using Salmonella typhimurium TA98, TA100, TA1535, and TA1538, methylsulfonylmethane did not induce any significant increase of His' revertants. In the in vitro chromosome aberration test using Chinese Hamster Lung (CHL) cells, no aberration effects were seen. In the in vivo evaluation using a micronucleus test, negative results were obtained. Accordingly, the results indicated that methylsulfonylmethane is not genotoxic and its use is unlikely to present a potential hazard.

키워드

참고문헌

  1. Ames, B. N., J. McCann, and E. Yamasaki. 1975. Methods of detecting carcinogens and mutagens with the Salmonella/ mammalian microsomal mutagenicity test. Mutat. Res. 31: 347-354 https://doi.org/10.1016/0165-1161(75)90046-1
  2. Baker, D. H. 1986. Utilization of isomers and analogs of amino acids and other sulfur-containing compounds. Prog. Food Nutr. Sci. 10: 133-178
  3. Barrager, E. and A. G. Schauss. 2003. Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: Additional data on pollen counts and symptom questionnaire. J. Altern. Complement. Med. 9: 15-16 https://doi.org/10.1089/107555303321222874
  4. Barrager, E., J. R. Veltmann, A. G. Schauss, and R. N. Schiller. 2002. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J. Altern. Complement. Med. 8: 167-173 https://doi.org/10.1089/107555302317371451
  5. Bertken, R. 1983. Crystalline DMSO: DMSO2. Arthritis Rheum. 26: 693-694 https://doi.org/10.1002/art.1780260525
  6. Blum, J. M. and R. I. Blume. 2004. The effect of MSM in the control of snoring. Integr. Med. 3: 24-30
  7. Cecil, K. M., A. Lin, B. D. Ross, and J. C. Egelhoff. 2002. Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: Effects of dietary supplementation. J. Comput. Assist. Tomogr. 26: 818-820 https://doi.org/10.1097/00004728-200209000-00026
  8. Ebisuzaki, K. 2003. Aspirin and methylsulfonylmethane (MSM): A search for common mechanisms, with implications for cancer prevention. Anticancer Res. 23: 453-458
  9. Gatehouse, D., S. Haworth, and T. Cebula. 1994. Recommendations for the performance of bacterial mutation assays. Mutat. Res. 312: 217-233 https://doi.org/10.1016/0165-1161(94)90037-X
  10. Giordanol, M., A. Noricil, and R. Hell. 2005. Sulfur and phytoplankton: Acquisition, metabolism and impact on the environment. New Phytologist 166: 371 https://doi.org/10.1111/j.1469-8137.2005.01335.x
  11. Heo, Y. J., K. S. Ko, J. H. Song, and Y. H. Cho. 2005. Profiling pyocins and competitive growth advantages of various Pseudomonas aeruginosa strains. J. Microbiol. Biotechnol. 15: 1368-1376
  12. Horvath, K., P. E. Noker, S. Somfai-Relle, R. Glavits, I. Financsek, and A. G. Schauss. 2002. Toxicity of methylsulfonylmethane in rats. Food Chem. Toxicol. 40: 1459-1462 https://doi.org/10.1016/S0278-6915(02)00086-8
  13. Jacob, S.W. 1983. The current status of MSM in medicine. Am. Acad. Med. Prev., U.S.A. 23: 16-17
  14. Jacob, S. W. and R. J. Herschler. 1983. Introductory remarks: Dimethylsulfoxide after twenty years. Ann. N.Y. Acad. Sci., U.S.A. 7: 86-92
  15. Jung, S. J., H. J. Kim, and H. Y. Kim. 2005. Quantitative detection of Salmonella typhimurium contamination in milk, using real time PCR. J. Microbiol. Biotechnol. 15: 1353-1358
  16. Kim, L. S., L. J. Axelrod, P. Howard, N. Buratovich, and R. F. Waters. 2006. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: A pilot clinical trial. Osteoarthritis Cartilage 14: 286-294 https://doi.org/10.1016/j.joca.2005.10.003
  17. Kumamoto, S., T. Hasegawa, S. Ueno, S. Kumamoto, and Y. Yoshikai. 2004. Suppressive effect of methylsulfonylmethane (MSM) on type II collagen-induced arthritis in DBA/1J mice. Jpn. Pharmacol. Ther. 32: 421-427
  18. Lee, H. Y., J. H. Park, S. H. Seok, S. A. Cho, M. W. Baek, D. J. Kim, Y. H. Lee, and J. H. Park. 2004. Dietary intake of various lactic acid bacteria suppresses type 2 helper T cell production in antigen-primed mice splenocyte. J. Microbiol. Biotechnol. 14: 167-170 https://doi.org/10.1159/000078108
  19. Maron, D. and B. N. Ames. 1983. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113: 173-215 https://doi.org/10.1016/0165-1161(83)90010-9
  20. Morton, J. I. and B. V. Siegel. 1986. Effects of oral dimethylsufoxide (DMSO) and dimethylsulfone (MSM) on murine autoimmune lymphoproliferative disease. Proc. Soc. Exper. Biol. Med. 183: 227-230
  21. Murav'ev, I., M. S. Venikova, G. N. Pleskovskaia, T. A. Riazantseva, and I. Sigidin. 1991. Effect of dimethyl sulfoxide and dimethyl sulfone on a destructive process in the joints of mice with spontaneous arthritis. Patol. Fiziol. Eksp. Ter. 2: 37-39
  22. Parcell, S. 2002. Sulfur in human nutrition and applications in medicine. Altern. Med. Rev. 7: 22-44
  23. Park, J. H., S. R. Yu, J. S. Yoon, and K. H. Baek. 2005. High level expression of recombinant human bone morphogenetic protein-4 in Chinese hamster ovary cells. J. Microbiol. Biotechnol. 15: 1397-1401
  24. Perez-Marrero, R., L. E. Emerson, and J. T. Feltis. 1988. A controlled study of dimethyl sulfoxide in interstitial cystitis. J. Urol. 140: 36-39 https://doi.org/10.1016/S0022-5347(17)41478-9
  25. Richmond, V. L. 1986. Incorporation of methylsulfonylmethane into guinea pig serum proteins. Life Sci. 39: 263-268 https://doi.org/10.1016/0024-3205(86)90540-0
  26. Swanson, B. N. 1985. Medical use of dimethyl sulfoxide (DMSO). Rev. Clin. Basic Pharm. 5: 1-33
  27. Usha, P. R. and N. MUR. 2004. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin. Drug. Invest. 24: 353-363 https://doi.org/10.2165/00044011-200424060-00005