Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Identification and Characterization of the wbpO Gene Essential for Lipopolysaccharide Synthesis in Vibrio vulnificus

  • Park Na-Young (Department of Food Science and Technology, School of Agricultural Biotechnology, and Center for Agricultural Biomaterials, Seoul National University) ;
  • Lee Jeong-Hyun (Department of Food Science and Technology, School of Agricultural Biotechnology, and Center for Agricultural Biomaterials, Seoul National University) ;
  • Lee Byung-Cheol (School of Life Sciences and Biotechnology, Korea University) ;
  • Kim Tae-Sung (School of Life Sciences and Biotechnology, Korea University) ;
  • Choi Sang-Ho (Department of Food Science and Technology, School of Agricultural Biotechnology, and Center for Agricultural Biomaterials, Seoul National University)
  • Published : 2006.05.01
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Abstract

A wbpO gene encoding a putative UDP-N-acetylo-galactosamine dehydrogenase was identified and cloned from Vibrio vulnificus. LPS production was altered by disruption of the wbpO gene through allelic exchanges. The function of the wbpO gene in virulence assessed in vitro and in mice revealed that WbpO is important in both the pathogenesis of V. vulnificus and the biosynthesis of LPS.

Keywords

References

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