한국전통의학지 (The Journal of Traditional Korean Medicine)

한국전통의학연구소 (Korea Bio Medical Science Institute)
권호 표지

교맥 에탄올 추출물의 멜라닌생성 억제효과

Inhibitory Effect of the Ethanol Extract of Fagopyrum escuentum on Melanin Synthesis

  • 김대성 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 노성택 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이장천 (상지대학교 한의과대학 본초방제학교실) ;
  • 임규상 (상지대학교 한의과대학 본초방제학교실) ;
  • 신미란 (한림대학교 한강성심병원 보철학과교실) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Kim, Dae-Sung (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • No, Seong-Taek (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Jang-Cheon (Department of Oriental Medical Prescription, Sangi University) ;
  • Lim, Kyu-Sang (Department of Oriental Medical Prescription, Sangi University) ;
  • Shin, Mee-Ran (Dept. of Prosthodontics, Hangcred Sacred Heart Hospital, Hallym University Medical Center) ;
  • Woo, Won-Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Mun, Yeun-Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 발행 : 2006.12.29
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초록

The aim of this study was to investigate the effect of ethanol extract of Fagopyrum escuentum(FE) on the melanogenesis. To determine whether ethanol extract of FE suppress melanin synthesis in cellular level, B16F10 melanoma cells were cultured in the presence of different concentrations of FE ethanol extract. In the present study, the author examined the effects of FE ethanol extract on cell proliferation, melanin contents, tyrosinase activity. Cell proliferation was slightly increased by treatment with ethanol extract of FE (25-200 ${\mu}$g/ml). The ethanol extract of FE effectively suppressed melanin contents at a dose of 100 ${\mu}$g/ml. It was observed that the color of cell pellets was totally whitened compared with the control. The ethanol extract of FE inhibited tyrosinase activity, regulate melanin biosynthesis as the key enzyme in melanogenesis. These results suggest that the ethanol extract of FE exerts its depigmenting effects through the suppression of tyrosinase activity. And it may be a potent depigmetation agent in hyperpigmentation condition.

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