Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Keum-Ryung-Ja-San, an Traditional Herbal Prescription, Ameliorates Depressive Behaviors in Mice

  • Jung Ji-Wook (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Lee Seung-Joo (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Yoon Byung-Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Kim Dong-Hyun (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Ryu Jong-Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, East-west Pharmaceutical Research Institute, College ofPharmacy, Kyung Hee University)
  • Published : 2006.06.01
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Abstract

Depression is a very difficult disease to be cured because several nervous systems are involved. In the present study, we evaluated the effects of Keum-Ryung-Ja-San (KRJS), a traditional herbal prescription, on depressive behaviors in mice using the forced swimming test. KRJS was given 1 h prior to the forced swimming test (50, 100, 200, an400 mg/kg, p.o.). The duration of immobility time in the forced swimming test was significantly reduced by KRJS treatment (200 mg/kg, P<0.05) and similar effects were observed with a classical antidepressant, imipramine (15 mg/kg, i.p.). With subchronic administrations of KRJS and its constituents at several doses for 1 week, a decreased duration of immobility time was observed with KRJS and Corydalis ternata (200 mg/kg, p.o. P<0.05). These results suggest that KRJS may have antidedpressive activities and CT may contribute to the antidepressive activity of KRJS.

Keywords

References

  1. Bejar, C., Wang, R.H., Weinstock, M. (1999). Effect of rivastigmine on scopolamine-induced memory impairment in rats. Eur. J. Pharmacol. 383, 231-240 https://doi.org/10.1016/S0014-2999(99)00643-3
  2. Braida, D., Paladini, E., Griffini, P., Lamperti, M., Maggi, A., Sala, M. (1996). An inverted V-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors. Eur. J. Pharmacol. 302, 13-20 https://doi.org/10.1016/0014-2999(96)00072-6
  3. Butterweck, V., Petereit, F., Winterhoff, H., Nahrstedt, A. (1998). Solubilized hypericin and pseudohypericin from Hypercum perforatum exert antidepressant activity in the forced swimming test. Planta Med. 64, 291-294 https://doi.org/10.1055/s-2006-957437
  4. Celik, T., Goren, M. Z., Cinar, K., Gurdal, H., Onder, F. O., Tan, A., Terzioglu, B., Bozdayi, A. M., Bozkaya, H., Vzunalimoglu, O., Yurdaydin, C. (2005). Fatigue of cholestasis and the serotoninergic neurotransmitter system in the rat. Hepatology 41, 731-737 https://doi.org/10.1002/hep.20617
  5. Dremencov, E., Gur, E., Lerer, B., Newman, E. M. (2003). Effects of chronic antidepressants and electroconvulsive shock on serotonergic neurotransmission in the rat hippocampus. Prog. Neuropsychophannacol. BioI. Psychiatry. 27, 729-739 https://doi.org/10.1016/S0278-5846(03)00123-4
  6. Gareri, P., Falconi, U., De Fazio, P., De Sarro, G. (2000). Conventional and new antidepressant drugs in the elderly. Prog. Neurobiol. 61, 353-396 https://doi.org/10.1016/S0301-0082(99)00050-7
  7. Hjorth, S., Bengtsson, H. J., Kullberg, A., Carlzon, D., Peilot, H., Auerbach, S. B. (2000). Serotonin autoreceptor function and antidepressant drug action. J. Psychopharmacol. 14, 177-185 https://doi.org/10.1177/026988110001400208
  8. Kalia, M. (2005). Neurobiological basis of depression: an update. Metabolism 54, 24-27
  9. Kim, B., Kim, H., Choi, J. W., Lee, C. K. (1996). The effects of Meliae toosendan Fructus on liver function. III. Effects of melianone and 28-deacetyl sendanin on drug metabolism and bile juice secretion. Saengyak Hakhoechi 27, 47-52
  10. Kim, S. H., Han, J., Seog, D. H., Chung, J. Y., Kim, N., Hong, P. Y., Lee, S. K. (2005). Antidepressant effect of Chaihu-ShuganSan extract and its constituents in rat models of depression. Life Sci. 76, 1297-1306 https://doi.org/10.1016/j.lfs.2004.10.022
  11. Lin, M. T., Chueh, F. Y., Hsieh, M. T., Chen, C. F. (1996). AntIhypertensive effects of DL-tetrahydropalmatine: an active principIe isolated from Corydalis. Clin. Exp. Pharmacol. Physiol. 23, 738-742 https://doi.org/10.1111/j.1440-1681.1996.tb01769.x
  12. Luo, L., Nong, W. J., Kong, L. D., Jiang, Q. G., Tan, R. X. (2000). Antidepressant effects of Banxia Houpu decoction, a traditional Chinese medicinal empirical formula. J. Ethnopharmacol. 73, 277-281 https://doi.org/10.1016/S0378-8741(00)00242-7
  13. Moller, H. J. and Volz, H. P. (1996). Drug treatment of depression in the 1990s. An overview of achievements and future possibilities. Drugs 52, 625-638 https://doi.org/10.2165/00003495-199652050-00001
  14. Muller, W. E. (2003). Current St. John's wort research from mode of action to clinical efficacy. Phannacol Res. 47, 101-109
  15. Nestler, E. J., Gould, E., Buncan, M., Duman, R. S., Greshenfeld, H. K., Hen, R., Koester, S., Lederhendler, I., Meaney, M., Robbins, T., Winsky, L., Zalcman, S. (2002). Preclinical models: status of basic research in dlepression. BioI. Psychiatry 52, 503-528 https://doi.org/10.1016/S0006-3223(02)01405-1
  16. Porsolt, R. D., Bertin, A., Jalfre, M. (1977a). Behavioral despair in mice: a primary screening test for antidepressant. Arch. Int. Pharmacodyn. Ther. 229, 327-336
  17. Porsolt, R. D., Le Pichon, M., Jalfre, M., Chatteljee, S. S. (1977b). Depression: a new animal model sensitive to antidepressant treatments. Nature 266, 730-732 https://doi.org/10.1038/266730a0
  18. Porsolt, R. D., Bertin, A., Jalfre, M. (1978). 'Behavioural despair' in rats and mice: strain differences and the effects of imipramine. Eur. J. Pharmacol. 51, 291-294 https://doi.org/10.1016/0014-2999(78)90414-4
  19. Shioda, K., Nisijima, K., Yoshino, T., Kato, S. (2004). Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine. Prog. Neuropsychopharmacol. Biol. Psychiatry. 28, 633-640 https://doi.org/10.1016/j.pnpbp.2004.01.013
  20. Swain, M. G. and Maric, M. (1997). Improvement in cholestasisassociated fatigue with a serotonin receptor agonist using a novel rat model of fatigue assessment. Hepatology 25, 291-294 https://doi.org/10.1002/hep.510250206
  21. Whooley, M.A. and Simon, G.E. (2000). Managing depression in medical outpatients. N. Engl. J. Med. 343, 1943-1950
  22. Yamamoto, T., Une, T. (2002). Animal models of psychiatric disorder and their validity--from the perspective of behavioral pharmacology. Nippon Yakurigaku Zasshi 120, 173-180 https://doi.org/10.1254/fpj.120.173
  23. Zhu, Y. P. (1998). Chinese Materia Medica Chemistry, Pharmacology and Applications. The Netherlands: Harwood Academic Publishers. 391-392; 445-449