Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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A Study on the Hazardousness Evaluation and the Inhalation Toxicity of Methylcyclohexane

메틸사이클로핵산 (methylcyclohexane)의 흡입독성과 유해성 평가

  • Kim Hyeon-Yeong (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency) ;
  • Lee Sung-Bae (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency) ;
  • Kang Min-Gu (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency) ;
  • Song Si-Hwan (Chemon)
  • 김현영 (산업안전보건연구원 화학물질안전보건센터) ;
  • 이성배 (산업안전보건연구원 화학물질안전보건센터) ;
  • 강민구 (산업안전보건연구원 화학물질안전보건센터) ;
  • 송시환 ((주) 켐온)
  • Published : 2006.06.01
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Abstract

From the harmfulness expectation test conducted through a toxicity anticipation program, methylcyclohexane turned out to be harmful and simulative, but no carcinogenicity was anticipated. In a four-hour acute inhalation toxicity test, the result showed that lethal concentration ($LC_{50}$) was 3,750 ppm (15,054 mg/L), which was identified as a harmful substance on the basis of the harmful substance classification standard $2 of the Industrial safety and health law. methylcyclohexane fell under the category $4(2,500 substance from the GHS standard acute toxicity harmfulness classification. Also, from subchronic inhalation toxicity test that included 6 hours a day, five days a week, and for 13 weeks, we could observe weight, activity, long term weight, blood and blood biochemical influence from the exposure of test substance. No-observed effect level (NOEL) was determined below $100{\sim}400ppm$ inboth male and female. This material falls under the Category 2 ($50{\sim}250ppm/6hours/90days$) in the GHS (Globally Harmonized System) standard trace long-term whole body toxicity repeated exposure, and can be classified as a harmful substance in accordance with the Industrial Safety and Health Law harmful substance standard $NOEL{\leq}0.5mg/L/6hr/90day$ (rat).

Keywords

References

  1. 강진석, 남기택, 박인승. 독성병리학 도감, 청구문회사 2001; 80-81
  2. 국립환경연구원. 화학물질 유해성 시험연구기관의 지정 등에 관한 규정, 국립환경연구원고시 1998; 41
  3. 김치년. 작업환경을 위한 TLV의 근거, 대한산업보건협회 월간산업보건 1998; 2: 23
  4. 노동부. 물질안전보건자료 작성 비치 등에 관한 기준, 노동부 1997
  5. 노동부. 화학물질별 취급 제조업체 현황, 노동부 2004
  6. 식품의약품안전청. 의약품등의 독성시험기준, 식품의약품 안전청 1999; 61
  7. 이귀영, 이종순. 임상병리파일, 의학문학사 1993; 71-87
  8. 이영순. 실험동물의학, 1991; 190-191
  9. 한국산업안전공단. MSDS, 한국산업안전공단 2004
  10. 産業中毒便覽. 後藤綢 外 1994; 531-532
  11. American Conference of Governmental Industrial Hygienists TLVs and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. Cincinatti, OH 2004; 5: 38
  12. Baker JT. MSDS Number: M391, 11. Toxicology information 1999; 5
  13. Boorman GA, Eustis SL, Elwell MR, Montgomery CA Jr, and Mackenzie WF. Pathology of the Fischer Rat. Academic Press, Inc 1990
  14. Casarett LJ and Doull J. The Basic Science of Poisons. New York: MacMillan Publishing Co., Toxicology 1975; 82
  15. EPA (Environmental Protection Agency). Health Effects Test Guidelines OPPTS 870.3465, 90-Day Inhalation Toxicity, US EPA 1998
  16. Farrar PL. Interstitial Pneumonia in Viral and Mycoplasml Antibody-Free Sprague Damlery Rats, ACLDA NEWSLETTER (American Committee on Laboratory Animal Diseases) 1997; 1: 18
  17. Gary AD, Mary BS and Sheila J. Comparative evaluation of chemical ranking and scoring methodologies, US EPA 1994
  18. Gary AB, Scot LE, Michael RE and Charles AM. Pathology of the Fisher Rat. Academic press, New York, 1990
  19. Globally. Harmonized System of Classification and Labelling of Chemicals (GHS), (United Nations NewYork and Geneva) 2003
  20. Gosselin RE, Smith RP, Hodge HC. Clinical Toxicology of Commercial Products, 5th ed. Baltimore 1984; 2: 151
  21. Greaves PH. istopathology of preclinical toxicity studies; Interpretation and relevance in drug evaluation, Elsevier 2000
  22. Kinkead ER et al. Aerosp Med Res Lab, Tech Rep AMRLTR, AMRL-TR-79-68 Proc Conf Environ Toxicol 1979; 154: 60
  23. Kinkead ER, Haun CC, Schneider MG, Vernot EH and Macewen JD. Chronic Inhalation Exposure of Experimental Animals to Methylcyclohexane. Air Force Aerospace Medical Research Laboratory Report 1985; 85: 032
  24. Lazarew NF. Zur toxikologie des benzins (The toxicology of gasoline) Arch Hyg 1929; 228-239
  25. Lehman KB and Flury F. Toxicology and Hygiene of Industrial Solvents, 1943; 95
  26. Lzmerov NF, Sanotsky IV and Sidorov KK. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT 1982; 82
  27. NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH) Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997; 204, 367
  28. OECD. OECD Guideline for Testing of Chemicals, TG 413: Subchronic Inhalation Toxicity: 90-day Study, Paris, France 1996
  29. OECD. OECD guideline for Testing of chemicals Draft proposal for a new guideline Acute Inhalation Toxicity - Fixed Concentration Procedure 2004; 433
  30. OECD, The 2000 OECD List of High Production Volume Chemicals, Organisation for Economic Co-Operation and Development, Paris, 2001
  31. Patty F (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers 1963; 1212
  32. Snyder R (ed.). Ethyl Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume 1: Hydrocarbons. Amsterdam-New York-Oxford: Elsevier 1987; 238-240
  33. Treon JF, Crutchfield WE Jr and Kitzmiller KV. The physiological response of animals to cyclohexane, methylcyclohexane, and certain derivatives of these compounds, J Ind Hyg Toxicol 1943; 25(8): 323-347