참고문헌
- Jeong, S. M. and Nah, S. Y.: Ginseng and ion channels: Are ginsenosides, active component of Panax ginseng, differential modulator of ion channels.: J.Ginseng Res. 29, 19-26 (2005) https://doi.org/10.5142/JGR.2005.29.1.019
-
Nah, S. Y., Park, H. J. and McCleskey, E. W.: A trace component of ginseng that inhibit
$Ca^{2+}$ channels through a pertussis toxin-sensitive G protein. Proc Natl Acad Sci USA 92, 8739-8743 (1995) -
Nah, S.Y. and McCleskey, E. W.: Ginseng root extract inhibits calcium channels in rat sensory neurons through a similar path, but different receptor, as
${\mu}-type$ opioids. J Ethnopharmacol 42, 45-51 (1994) https://doi.org/10.1016/0378-8741(94)90022-1 -
Kim, H. S., Lee, J. H., Koo, Y. S. and Nah, S. Y.: Effects of ginsenosides on
$Ca^{2+}$ channels and membrane capacitance in rat adrenal chromaffin cells. Brain Res Bull. 46, 245-251 (1998) https://doi.org/10.1016/S0361-9230(98)00014-8 -
Choi, S., Jung, S. Y., Kim, C. H., Kim, H. S., Rhim, H., Kim, S. C. and Nah, S. Y.: Effect of ginsenosides on voltagedependent
$Ca^{2+}$ channel subtypes in bovine chromaffin cells. J. Ethnopharmacol. 74, 75-81 (2001) https://doi.org/10.1016/S0378-8741(00)00353-6 -
Rhim, H., Kim, H., Lee, D. Y., Oh, T. H. and Nah, S. Y.: Ginseng and ginsenoside
$Rg_3$ , a newly identified active ingredient of ginseng, modulate$Ca^{2+}$ channel currents in rat sensory neurons. Eur. J. Pharmacol. 436, 151-158 (2002) https://doi.org/10.1016/S0014-2999(01)01613-2 -
Lee, J. H., Jeong, S. M., Kim, J. H., Lee, B. H., Yoon, I. S., Lee, J. H.,Choi, S. H., Lee, S. M., Park, Y. S., Lee, J. H., Kim, S. H., Kim, H. C., Lee, B. Y. and Nah, S. Y.: Effects of ginsenosides and their metabolites on voltage-dependent
$Ca^{2+}$ channel subtypes. Mol. Cells 21, 52-62 (2006) -
Jeong, S. M., Lee, J. H., Kim, J. H, Lee, B. H., Yoon, I. S., Lee, J. H., Kim, D. H., Rhim, H., Kim, Y. and Nah, S. Y.: Stereospecificity of ginsenoside
$Rg_3$ action on ion channels. Mol. Cells 18, 383-389 (2004) -
Lee, J. H., Jeong, S. M., Kim, J. H., Lee, B. H., Yoon, I. S., Lee, J. H., Choi, S. H., Kim, D. H., Rhim, H., Kim, S. S., Kim, J. I., Jang, C. G., Song, J. H. and Nah, S. Y.: Characteristics of Ginsenoside
$Rg_3$ -Mediated Brain$Na^+$ Current Inhibition Mol Pharmacol. 68, 1114-1126 (2005) https://doi.org/10.1124/mol.105.015115 - Changeux, J. and Edelstein, S. J.: Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors. Curr. Opin. Neurobiol. 11, 369-377 (2001) https://doi.org/10.1016/S0959-4388(00)00221-X
-
Tachikawa, E., Kudo, T., Kashimoto, T. and Takashshi, E.: Ginseng saponins reduce acetylcholine-evoked
$Na^+$ influx and catecholamine secretion in bovine adrenal chromaffin cells. J Pharmacol Exp Ther. 273, 629-636 (1995) - Campos-Caro, A., Smillie, F. I., Del Toro, E. D., Rovira, J. C., Vicente-Agullo, F., Chapuli, J., Juiz, J. M., Sala, S., Sala, F., Ballesta, J. and Criado, M.: Neuronal nicotinic acetylcholine receptors on bovine chromaffin cells: cloning, expression, and genomic organization of receptor subunits. J. Neurochem. 68, 488-497 (1997) https://doi.org/10.1046/j.1471-4159.1997.68020488.x
- Choi, S., Jung, S. Y., Lee, J. H., Sala, F., Criado, M., Mulet, J., Valor L. M., Sala, S., Engel, A. G. and Nah, S. Y.: Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur. J. Pharmacol. 442, 37-45 (2002) https://doi.org/10.1016/S0014-2999(02)01508-X
-
Sala, F., Mulet, J., Choi, S., Jung, S. Y., Nah, S. Y., Rhim, H., Valor, L. M., Criado, M. and Sala, S.: Effects of ginsenoside
$Rg_2$ on human neuronal nicotinic acetylcholine receptors. J. Pharm. Exp. Ther. 301, 1052-1059 (2002) https://doi.org/10.1124/jpet.301.3.1052 - Peters, J. A., Hales, T. G. and Lambert, J. J.: Molecular determinants of single channel conductance and ion selectivity in the Cys-loop family: insight from the 5-HT3 receptor. Trends Pharmacol. Sci. 26, 587-594 (2005) https://doi.org/10.1016/j.tips.2005.09.011
-
Choi, S., Lee, J. H., Oh, S., Rhim, H., Lee, S. M. and Nah, S. Y.: Effects of ginsenoside
$Rg_2$ on the$5-HT_3$ receptor-mediated ion current in Xenopus oocytes. Mol. Cells 15, 108-113 (2003) -
Lee, B. H., Jeong, S. M., Lee, J. H., Kim, D. H., Kim, J. H., Kim, J. I., Shin, H. C., Lee, S. M. and Nah, S. Y.: Differential effect of ginsenoside metabolites on the
$5-HT_{3A}$ receptor-mediated ion current in Xenopus oocytes. Mol. Cells 17, 51-56 (2004) - Camilleri, M., Northcutt, A. R., Kong, S., Dukes, G. E., McSorley, D. and Mangel, A. W.: Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial. Lancet. 355, 1035-1040 (2000) https://doi.org/10.1016/S0140-6736(00)02033-X
- Polati, E., Verlato, G., Finco, G., Monsaner, W., Grosso, S., Gottin, L., Pinaroli, AM., and Ischia, S.: Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting. Anesth. Analg. 85, 395-399 (1997) https://doi.org/10.1097/00000539-199708000-00027
- Min, K. T., Koo, B. N., Kang, J. W., Bai, S. J., Ko, S. R. and Cho, Z. H.: Effect of ginseng saponins on the recombinant serotonin type 3A receptor expressed in xenopus oocytes: implication of possible application as an antiemetic. J. Altern. Complement Med. 9, 505-510 (2003) https://doi.org/10.1089/107555303322284794
- Kim, J. H., Lee, J. H., Jeong, S. M., Lee, B. H., Yoon, I. S., Choi, S. H. and Nah, S.Y.: Effect of ginseng saponins on a rat visceral hypersensitivity model. Biol. Pharm. Bull. 28, 2120-2124 (2005a) https://doi.org/10.1248/bpb.28.2120
- Kim, J. H., Yoon, I. S., Lee, B. H., Choi, S. H., Lee, J. H., Jeong, S. M., Kim, S. C., Park, C. K., Lee, S. M. and Nah, S. Y.: Effects of Korean red ginseng extract on cisplatininduced nausea and vomiting. Arch. Pharm. Res. 28, 413- 420 (2005b) https://doi.org/10.1007/BF02977670
- Dingledine, R., Borges, K., Bowie, D. and Traynelis, S. F.: Glutamate receptor ion channels. Pharmacol. Rev. 51, 7-62 (1999)
-
Kim, Y. C., Kim, S. R., Markelonis, G. J. and Oh, T. H.: Ginsenosides
$Rb_1\;and\;Rg_3$ protect cultured rat cortical cells from glutamate-induced neurodegeranation. J. Neurosci. Res. 53, 426-432 (1998) https://doi.org/10.1002/(SICI)1097-4547(19980815)53:4<426::AID-JNR4>3.0.CO;2-8 - Seong, Y. H., Shin, C. S., Kim, H. S. and Baba, A.: Inhibitory effect of ginseng total saponins on glutamate-induced swelling of cultured atrocytes. Biol. Pharm. Bull. 18, 1776-1778 (1995) https://doi.org/10.1248/bpb.18.1776
-
Abe, K., Cho, S. I., Kitagawa, I., Nishiyama, N. and Saito, H.: Differential effects of ginsenoside
$Rb_1$ and malonylginsenoside$Rb_1$ on long-term potentiation in the dentate gyrus of rats. Brain Res. 649, 7-11 (1994) https://doi.org/10.1016/0006-8993(94)91042-1 - Yoon, S. R., Nah, J. J., Shin, Y. H., Kim, S. K., Nam, K. Y., Choi, H. S., Nah, S. Y.: Ginsenosides induce differential antinocicepion and inhibit substance P induced-nociceptive response in mice. Life Sci. 62, PL319-PL325 (1998) https://doi.org/10.1016/S0024-3205(98)00168-4
- Nah, J. J., Choi, S., Kim, Y. H., Kim, S. C., Nam, K. Y., Kim, J. K. and Nah, S. Y.: Effect of spinally administered ginseng total saponin on capsaicin-induced pain and excitatory amino acid-induced nociceptive responses. J. Ginseng Res. 23, 38-43 (1999)
- Lee, J. H., Kim, S. H., Kim, D., Hong, H. N. and Nah, S. Y.: Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainate-induced neurotoxicity in rat hippocampus. Neurosci. Lett. 325, 129-133 (2001) https://doi.org/10.1016/S0304-3940(02)00256-2
- Chu, G. X., and Chen, X.: Protective effect of ginsenosides on acute cerebral ischemia-reperfusion injury of rats. China J Pharmacol Toxicol. 3, 18-23 (1989)
- Chu, G. X., and Chen, X. Anti-lipid peroxidation and protection of ginsenosides against cerebral ischemia-reperfusion injury of rats. Acta Pharmacol Sin. 11, 119-123 (1990)
- Lim, J. H., Wen, T. C., Matsuda, S., Tanaka, J., Maeda, J., Peng, H., Aburaya, J., Ishihara, K. and Sakanaka, M. Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root. Neurosci. Res. 28, 191-200 (1997) https://doi.org/10.1016/S0168-0102(97)00041-2
- Lee, J. H., Kim, S. H., Kim D, Hong, H. N. and Nah, S. Y. (2001) Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainate-induced neurotoxicity in rat hippocampus. Neurosci. Lett. 325, 129-133 (2001) https://doi.org/10.1016/S0304-3940(02)00256-2
-
Choi, S., Rho, S. H., Jung, S. Y., Kim, S. C., Park, C. S. and Nah, S. Y.: A novel activation of
$Ca^{2+}$ -activated$Cl^-$ channel in Xenopus oocytes by ginseng saponins: evidence for the involvement of phospholipase C and intracellular$Ca^{2+}$ mobilization. British J. Pharmacol. 132, 641-648 (2001) https://doi.org/10.1038/sj.bjp.0703856 -
Choi, S., Kim, H. J., Ko, Y. S., Jeong, S. W., Kim, Y. I., Simonds, W. F., Oh, j. W. and Nah, S. Y.:
$G{\alpha}_{q/11}$ coupled to mammalian$PLC{\beta}3$ -like enzyme mediates the ginsenoside effect on$Ca^{2+}$ -activated$Cl^-$ current in the Xenopus oocyte. J. Biol. Chem. 276, 48797-48802 (2001) https://doi.org/10.1074/jbc.M104346200 - Jeong, S. M., Lee, J. H., Kim, S., Rhim, H., Lee, B.H., Kim, J. H., Oh, J. W., Lee, S. M. and Nah, S. Y. Ginseng saponins induce store-operated calcium entry in Xenopus oocytes. Br. J. Pharmacol. 142, 585-593 (2004) https://doi.org/10.1038/sj.bjp.0705797
- Berridge, M. J., Bootman, M. D. and Lipp, P.: Calcium – a life and death signal. Nature, 395, 645-668 (1998) https://doi.org/10.1038/27094
피인용 문헌
- Enhancement of low molecular weight ginsenosides from low-quality ginseng through ultra-high-pressure and fermentation processes vol.237, pp.3, 2013, https://doi.org/10.1007/s00217-013-2007-9