Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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In vitro Cytotoxic Activity of Biflavonoid against P388 Murine Lymphocytic Leukemia Cells

  • Lee, Jae-Sook (Department of Beauty Coordiation, Cheongyang College) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences ,Wonkwang University)
  • Published : 2006.10.25
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Abstract

Biflavonoid (1) showed no antimicrobial activity at a concentration of 150 ${\mu}$g/disc. However, the crude extract of Quintinia acutifolia Kirk inhibited the growth of Bacillus subtilis and the dermatophytic fungus Trichophyton mentagrophytes. 2',3'-Dihydroochanaflavone (1) showed some cytotoxicity with IC$_{50}$ value of 3.1 ${\mu}$g/mL against P388 murine lymphocytic leukemia cells (positive control: mitomycin C IC$_{50}$ 0.06 ${\mu}$g/mL). The structure was determined by Spectroscopic methods.

Keywords

References

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