Archives of Pharmacal Research

  • 제29권1호
  • /
  • Pages.40-45
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  • 2006
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Synthesis of Diacetoxy Acetal Derivatives of Santonin and their Enhancing Effects on HL-60 Leukemia Cell Differentiation

  • Kim, Seung-Hyun (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) ;
  • Chung, Sun-Young (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) ;
  • Kim, Tae-Sung (School of Life Sciences and Biotechnology, Korea University) ;
  • Choi, Bo-Gil (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
  • 발행 : 2006.01.01
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초록

Several diacetoxy acetal analogues have been synthesized from santonin and assessed for their ability of inducing or enhancing the differentiation of human HL-60 leukemia cells. The compounds themselves had little effect on HL-60 cell differentiation. However, three analogues, 2a, 3a, and 5b, synergistically enhanced 1,25-dihydroxyvitamin $D_3[1,25-(OH)_2D_3]-induced$ HL-60 cell differentiation when combined with 5 nM of dihydroxyvitamin $D_3[1,25(OH)_2O_3]$, a well-known differentiation inducer. Especially, the compound 5b profoundly enhanced the $1,25-(OH)2O_3]-induced$ HL-60 cell differentiation.

키워드

참고문헌

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