Potential Suppression of Dental Caries by Maltosyl-Mannitol Produced by Bacillus stearothermophilus Maltogenic Amylase

  • Cho Kil-Soon (School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University) ;
  • Shin Sang-Ick (School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University) ;
  • Cheong Jong-Joo (School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University) ;
  • Park Kwan-Hwa (School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University) ;
  • Moon Tae-Wha (School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University)
  • 발행 : 2006.03.01

초록

Maltosyl (G2)-mannitol, produced by the transglycosylation of mannitol with maltotriose by Bacillus stearothermophilus maltogenic amylase, was not found to support lactic acid production by Streptococcus sobrinus NRRL 14555. Furthermore, the synthesis of water-insoluble glucans from maltosyl-mannitol by S. sobrinus NRRL 14555 was much lower than that from xylitol or mannitol. Consequently, these results suggest that maltosyl-mannitol could be used as a noncariogenic sugar substitute in food products.

키워드

참고문헌

  1. Cha, H. J., H. G. Yoon, Y. W. Kim, H. S. Lee, J. W. Kim. K. S. Kweon, B. H. Oh, and K. H. Park. 1998. Molecular and enzymatic characterization of a maltogenic amylase that hydrolyzes and transglycosylates acarbose. Eur. J. Biochem. 253: 251-262 https://doi.org/10.1046/j.1432-1327.1998.2530251.x
  2. Cho, J. S., S. S. Yoo, T. K. Cheong, M. J. Kim, Y. Kim, and K. H. Park. 2000. Transglycosylation of neohesperdin dihydrochalcone by Bacillus stearothermophilus maltogenic amylase. J. Agric. Food Chem. 48: 152-154 https://doi.org/10.1021/jf991044y
  3. Chun, J. Y., I. H. Ryu, J. S. Park, and K. S. Lee. 2002. Anticaries activity of antimicrobial material from Bacillus alkalophilsphaggy JY-827. J. Microbiol. Biotechnol. 12: 18-24
  4. Embuscado, M. E. and S. K. Patil. 2001. Erytritol, pp. 235- 254. In L. O. Nabors (ed.), Alternative Sweeteners. Marcel Dekker, Inc., New York, U.S.A
  5. Featherstone, J. D. 1994. Effects of isomalt sweetener on the caries process: A review. J. Clin. Dent. 5: 82-85
  6. Ikeda, T. 1982. Sugar substitute: Reasons and indications for their use. Int. Dent. J. 32: 33-43
  7. Imai, S., K. Takeuchi, K. Shibata, S. Yoshikawa, S. Kitahata, S. Okada, S. Araya, and T. Nisizawa. 1984. Screening of sugars inhibitory against sucrose-dependent synthesis and adherence of insoluble glucan and acid production by Streptococcus mutans. J. Dent. Res. 63: 1293-1297 https://doi.org/10.1177/00220345840630110801
  8. Jeon, E. J., I. H. Jung, K. S. Cho, E. S. Seo, D. Kim, S.-J. Lee, K. H. Park, and T. W. Moon. 2003. Low cariogenicity of maltosyl-erysthritol, major transglycosylation product of erythritol, by Bacillus stearothermophilus maltogenic amylase. J. Microbiol. Biotechnol. 13: 815-818
  9. Kawanabe, J., M. Hirasawa, T. Takeuchi, T. Oda, and T. Ikeda. 1992. Noncariogenicity of erytritol as a substrate. Caries Res. 26: 358-362 https://doi.org/10.1159/000261468
  10. Kim, D., S.-J. Ryu, S.-J. Heo, D.-W. Kim, and H.-S. Kim. 1999. Characterization of a novel carbohydrase from Lipomyces starkeyi KSM 22 for dental application. J. Microbiol. Biotechnol. 9: 260-264 https://doi.org/10.1159/000015891
  11. Kim, Y. K., M. J. Kim, C. S. Park, and K. H. Park. 2000. Modification of sorbitol by transglycosylation using Bacillus stearothermophilus maltogenic amylase. Food Sci. Biotechnol. 11: 401-406
  12. Le, A. S. and K. B. Muldering. 2001. Sorbitol and mannitol, pp. 317-324. In L. O. Nabors (ed.), Alternative Sweeteners. Marcel Dekker, Inc., New York, U.S.A
  13. Lee, H. Y., M. J. Kim, J. S. Baek, H. S. Lee, H. J. Cha, S. B. Lee, T. W. Moon, E. S. Seo, D. Kim, C. S. Park, and K. H. Park. 2003. Preparation and characterization of maltosylsucrose isomers produced by transglycosylation of maltogenic amylase from Bacillus stearothermophilus. J. Mol. Cat. B. 26: 293-305 https://doi.org/10.1016/j.molcatb.2003.08.003
  14. Loesche, W. J. 1986. Role of Streptococcus mutans in human dental decay. Microbiol. Rev. 50: 353-380
  15. Schiweck, H. and S. C. Ziesentiz. 1995. Physicological properties of polyols in comparison with easily metabolisable saccharides, pp. 56-84. In T. H. Grenby (ed.), Advances in Sweeteners. Blackie Academic & Professional, Glasgow, Scotland
  16. Wisselink, H. W. R., A. Weusthuis, G. Eggink, J. Hugenholtz, and G. J. Grobben. 2002. Mannitol production by lactic acid bacteria: A review. Int. Dairy J. 12: 151-161 https://doi.org/10.1016/S0958-6946(01)00153-4
  17. Yanagida, A., T. Kanda, M. Tanabe, F. Matsudaira, and J. G. O. Cordeiro. 2000. Inhibitory effects of apple polyphenols and related compounds on cariogenic factors of mutans streptococci. J. Agric. Food Chem. 48: 5666-5671 https://doi.org/10.1021/jf000363i