Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Gamisingi-tang and Gamicheongpye-tang on Airway Mucus Secretion

가미신기탕(加味腎氣湯) 및 가미청폐탕(加味淸肺湯)이 기도점액 분비 및 기관평활근 긴장도에 미치는 영향

  • Kim Yun-Hee (Department of Pediatrics, College of Oriental Medicine, Daejeon University) ;
  • Kang Tak-Lim (Department of Pharmacology, College of Oriental Medicine, Daejeon University) ;
  • Han Dal-Soo (Department of Pediatrics, College of Oriental Medicine, Daejeon University)
  • 김윤희 (대전대학교 한의과대학 소아과학 교실) ;
  • 강탁림 (대전대학교 한의과대학 약리학교실) ;
  • 한달수 (대전대학교 한의과대학 소아과학 교실)
  • Published : 2006.02.01
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Abstract

In the present study, the author intended to investigate whether two oriental medical prescriptions named GSGT and GCPT significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells. Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presen+ce of GSGT or GCPT to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed dy measuring lactate dehydrogenase(LDH) release. Also, the effects of GSGT and GCPT on contractility of isolated tracheal smooth muscle were investigated. (1) GSGT did not affect mucin release without cytotoxicity ; (2) GCPT significantly stimulated mucin release from cultured HTSE cells, with significant cytotoxicity ; (3) GSGT and GCPT did not affect contractility of isolated tracheal smooth muscle. We suggest that the effects of GCPT and its components should be further investigated and it is of great value to find, from oriental medical prescriptions, novel agents which have potent expectorant effects on mucin secretion from airway goblet cells.

Keywords

References

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