Food Science and Preservation (한국식품저장유통학회지)

The Korean Society of Food Preservation (한국식품저장유통학회)
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Anti-oxidant and Anti-tumor Activities of Crude Extracts by Gastrodia elata Blume

천마추출물의 항산화 및 항암 활성

  • Heo Jin-Chul (Department of Food Science & Technology, Kyungpook National University) ;
  • Park Ja-Young (Department of Food Science & Technology, Kyungpook National University) ;
  • An Sang-Mi (Department of Food Science & Technology, Kyungpook National University) ;
  • Lee Jin-Man (Department of Food Science & Technology, Kyungpook National University) ;
  • Yun Chi-Young (Department of Herbal BioFood Science, Kyongbuk College of Science) ;
  • Shin Heung-Mook (College of Oriental Medicine, Dongguk University) ;
  • Kwon Taeg-Kyu (Department of Immunology, Keimyung University) ;
  • Lee Sang-Han (Department of Food Science & Technology, Kyungpook National University)
  • Published : 2006.02.01
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Abstract

Gastrodia elata Blume is a major imp0l1ant medicinal resource in Korea. In order to confirm the biological activities of Gastrodia elata Blume, we carried out various in vitro assays. Of them, anti-oxidant and anti-tumor activities were detected from assays. The prototype of Gastrodia elata Blume extracts was used for 1he evaluation of DPPH, FRAP, hydroxyradical scavenging assay as anti-oxidant assays, as well as anti-tumor asctivities as wound assay and invasion assay. As a result, the prototype of Gastrodia elata Blume extracts showed potent anti-oxidative activity and anti-tumor activity in vitro. These above results suggest that 1he Gastrodia elata Blume extracts could have potential to alleviate oxidation process, cell motility activity, and tumorigenesis.

한의학에서 천마는 여러 치료의 목적으로 사용이 되는 한약재이다. 본 연구는 천마의 항산화활성과 항암 효과를 검증하기 위하여 실시하였다. 천마와 이를 이용한 식음료를 이용하여 항산화활성과 암세포를 이용한 세포의 운동성을 측정하였다. 항산화활성의 경우 DPPH, FRAP, Hydroxyl radical assay를 실시하였으며, 항암효과를 확인하기 위하여 wound / invasion assay를 실시하였다. 실험 결과 천마의 항산화 활성은 매우 뛰어난 것으로 나타났으며, 특히 DPPH / FRAP 실험에서 높은 활성을 보여주었다. 항암효과로 세포의 운동성을 확인한 결과 천마와 제품군 모두에서 세포의 운동성을 억제하는 효과가 매우 높은 것으로 나타났다. 천마는 항산화 효과와 함께 암세포의 운동성을 억제하는 항암효과를 가지는 것으로 나타났다.

Keywords

References

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