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Polymeric Waveguide Bio Sensors with Bragg Gratings

브래그 격자 광도파로형 바이오 센서

  • Lee, Jae-Hyun (Nano-bio Photonics Lab, Department of Electronics Engineering, Pusan National University) ;
  • Kim, Gyeong-Jo (Nano-bio Photonics Lab, Department of Electronics Engineering, Pusan National University) ;
  • Oh, Min-Choel (Nano-bio Photonics Lab, Department of Electronics Engineering, Pusan National University)
  • 이재현 (부산대학교 전자공학과 나노바이오광소자연구실) ;
  • 김경조 (부산대학교 전자공학과 나노바이오광소자연구실) ;
  • 오민철 (부산대학교 전자공학과 나노바이오광소자연구실)
  • Published : 2006.02.01

Abstract

Biophotonic sensors based on polymer waveguide with Bragg reflection grating are demonstrated in this work. Waveguide Bragg reflectors were designed by using the effective index method and the transmission matrix method. The grating pattern was formed by exposing the laser interference pattern on a photoresist. On top of the inverted rib waveguide, the Bragg reflection grating was inscribed by the O2 plasma etching. In order to perform the bio-molecule detection experiment, a calixarene molecule was self-assembled on top of thin Au film deposited on the waveguide Bragg reflector. To measure the response of the sensor, several PBS solutions with different concentrations of potassium ion from 1 pM to $100\;{\mu}M$ were dropped on the sensor surface. The shift of Bragg reflection wavelength was observed from the fabricated sensor device, which was proportional to the concentration of potassium ion ranging from 1 pM to 108 pM.

본 논문에서는 집적 광학 광도파로 소자 기술을 적용하여 생화학 물질의 성분을 정밀하게 측정 가능한 광소자로서 폴리머 광도파로와 브래그 격자를 이용하는 구조를 최초로 제안하였다. 유효굴절률법과 전송행렬법을 이용하여 최적의 감도를 가지는 브래그 격자 광도파로를 설계하였으며 코아와 하부 클래딩의 굴절률이 각각 1.540, 1.430인 폴리머를 이용하여 코아 두께가 $3{\mu}m$ 인 구조의 반전립 광도파로를 제작하였다. 코아 층까지 완성된 도파로 위에 레이저 빔 간섭계와 플라즈마 에칭을 이용하여 격자를 형성한 뒤 격자표면에 20 nm 두께의 Au층을 증착하고 칼릭사린(calixarene) 단분자층을 만들어 바이오센서를 제작하였다. 제작된 광센서를 이용하여 PBS(phosphate bufferedsaline) 용액에 함유된 $K^+$의 농도에 따라 브래그 반사픽이 단파장으로 이동하는 것을 관찰할 수 있었다.

Keywords

References

  1. Min-Cheol Oh, Wol-Yon Hwang, Young-Ouk Noh, Hyung-Jong Lee, and Seon-Gyu Han, 'Reliable low-cost polymeric optical waveguide device,' OECC/COIN2004, Yokkohama Japan, 14F2-3, pp. 558-559, July 2004
  2. Min-Cheol Oh, Myung-Hyun Lee, Joo-Heon Ahn, HyungJong Lee, and Sean Gyu Han, 'Polymeric wavelength filters with polymer gratings,' Applied Physics Letters, Vol. 72, No. 13, March 1998
  3. F. Prieto, B. Sepulveda, A. Calle, A. Liobera, C. Dominguez, and L. M. Lechuga, 'Integrated Mach-Zehnder interferometer based on ARROW structures for biosensor applications,' Sensors and Actuators B, Vol. 92, pp. 151-158, 2003 https://doi.org/10.1016/S0925-4005(03)00257-0
  4. Ch. Stamm, R. Dangel, W. Lukosz, 'Biosensing with the integrated-optical difference interferometer dual-wavelength operation,' Optics Communications, Vol. 153, pp. 347-359, 1998 https://doi.org/10.1016/S0030-4018(98)00194-1
  5. Stefan Busse, Josua Kashammer, Stephan Kramer, Silvia Mittler, 'Gold and thiol surface functionalized optical Mach-Zehnder interferometer for sensing purposes.' Sens. And Actuators B, Vol. 60, pp. 148-154, 1999 https://doi.org/10.1016/S0925-4005(99)00264-6
  6. D. Filenko, T. Gotszalk, Z. Kazantseva, O. Rabinovych, I. Koshets, Yu. Shirshov, V. Kalchenko and I.W. Rangelow, 'Chemical gas sensors based on calixarene-coated discontinuous gold films,' Sensors and Actuators B, Vol. 111-112, pp. 264-270, 2005 https://doi.org/10.1016/j.snb.2005.06.066
  7. A. V. Nabok, A. K. Hassan, A. K. Ray, O. Omar and V. I. Kalchenko, 'Study of adsorption of some organic molecules in calix[4]resorcinolarene LB films by surface plasmon resonance,' Sensors and Actuators B, Vol. 45, pp. 114-121, 1997
  8. Katsunari Okamoto, Fundamentals of Optical Waveguides, Academic Press, 2000
  9. L. A. Coldren and S. W. Corzine, Diode Lasers and Photonic Integrated Circuits, Wiley-Interscience, chapter 3, 1995