Nuclear Medicine and Molecular Imaging

  • 제40권2호
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  • Pages.96-105
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  • 2006
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  • 1869-3474(pISSN)
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  • 1869-3482(eISSN)
대한핵의학회 (The Korean Society of Nuclear Medicine)
권호 표지

핵의학적 기법을 이용한 유전자 치료 영상법

Monitoring Gene Therapy by Radionuclide Approaches

  • 민정준 (전남대학교 의과대학 핵의학교실)
  • Min, Jung-Joon (Institute for Molecular Photonic Imaging Research, Department of Nuclear Medicine, Chonnam National University Hwasun Hospital)
  • 발행 : 2006.04.29
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초록

Molecular imaging has its root in nuclear medicine and gene therapy monitoring. Therefore, recent progress in the development of non-invasive imaging technologies, particularly nuclear medicine, should allow molecular imaging to play a major role in the field of gene therapy. These tools have recently been validated in gene therapy models for continuous quantitative monitoring of the location, magnitude, and time-variation of gene delivery and/or expression. This article reviews the use of radionuclide imaging technologies as they have been used in imaging gene delivery and gene expression for gene therapy applications. The studios published to date lend support that noninvasive imaging tools will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human gene therapy.

키워드

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