Korean Journal of Biological Psychiatry (생물정신의학)
- Volume 13 Issue 4
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- Pages.260-266
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- 2006
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
No Associations between Schizophrenia and D22S280 Marker on Synapsin III Gene in Korean Males
한국인 남자에서 Synapsin III 유전자의 D22S280 표지자와 정신분열병의 연합연구
- Lee, Yu-Sang (Yong-In Mental Hospital) ;
- Park, Chong-Won (Yong-In Mental Hospital) ;
- Lee, Seung-Yeoun (Department of Applied Mathematics, Sejong University) ;
- Lee, Suk-Jin (Yong-In Mental Hospital) ;
- Park, Yong-Bum (Yong-In Mental Hospital) ;
- Shin, Yoon-Sik (Yong-In Mental Hospital) ;
- Yoo, Jang-Keun (Yong-In Mental Hospital) ;
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Hong, Kyung Sue
(Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Seoul Hospital) ;
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Yang, Byung-Hwan
(Department of Neuropsychiatry, College of Medicine and the Mental Health Research Institute, Hanyang University)
- 이유상 (용인정신병원) ;
- 박종원 (용인정신병원) ;
- 이승연 (세종대학교 응용수학과) ;
- 이석진 (용인정신병원) ;
- 박용범 (용인정신병원) ;
- 신윤식 (용인정신병원) ;
- 유장근 (용인정신병원) ;
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홍경수
(성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
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양병환
(한양대학교 의과대학 신경정신과학교실)
- Published : 2006.11.30
Abstract
Objectives : Synapsin III near VCFS region on chromosome 22q affects. It could be an interesting candidate gene for schizophrenia. D22S280 is a highly polymorphic genetic marker residing in synapsin III. We examined association of D22S280 marker on synapsin III with Korean patients with schizophrenia. Methods : The subjects were 46 male Korean patients with schizophrenia and 60 male normal controls. Using polymerase chain reaction, gel electrophoresis, ABI 310 genetic analyzer, and GeneScan Collection 3.1 software, we confirmed genotypes of D22S280 marker. We examined Hardy-Weinberg equilibrium and case-control association using SAS/Genetic 9.1.3. Results : Genotypes of both schizophrenia and control groups were in Hardy-Weinberg equilibrium. We could not find any significant statistical differences in allele-wise(