Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of Eucalyptus and Geranium on Production of IL-2 and IL-4 in Mouse Splenocytes

Eucalyptus와 geranium이 마우스 splenocytes에서 IL-2 및 IL-4 생성에 대한 효과

  • Cha Bong Kyu (Dept. of Microbiology, Kosin University College of Medicine) ;
  • Chang Myung Woong (Dept. of Microbiology, Kosin University College of Medicine) ;
  • Jeong Young Kee (Dept. of Life Science and Biotechnology, Dong-Eui University) ;
  • Kim Kwang Hyuk (Dept. of Microbiology, Kosin University College of Medicine)
  • 차봉규 (고신대학교 의과대학 미생물학교실) ;
  • 장명웅 (고신대학교 의과대학 미생물학교실) ;
  • 정영기 (동의대학교 자연과학대학 생명응용과학과) ;
  • 김광혁 (고신대학교 의과대학 미생물학교실)
  • Published : 2006.02.01
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Abstract

Aromatherpy is the controlled use of essential oils to promote health and well-being. In this work we have investigated the effect of eucalyptus and geranium on the production of interleukin-2 (IL-2) and interleukin4 (IL-4). Mouse splenocytes were incubated with essential oils. The culture supernatants of mouse splenocytes exposed with these oils were harvested to assay IL-2 and IL-4 production. The quantitative changes of IL-2 in splenocytes culture supernatants after exposure with these oils were decreased at high doses, but increased at low doses. But its of IL-4 were increased generally at high doses of eucalyptus. In case of the exposure of geranium, its of IL-4 were dose-dependently increased. These kinds of essential oils showed the probability to improve IL-2- and IL-4-related immune responses at the optimum exposure.

마우스의 비장세포에 아로마 에센셜 오일 중 eucalyptus나 geranium에 노출된 마우스비장세포로부터 생성되는 in-terleukin (IL)-2와 IL-4를 정량 분석하였다. Eucalyptus를 노출시킨 비장세포에서 IL-2의 생성은 저농도의 오일 노출의 경우 대조군에 비하여 증가한 반면 고농도에서는 감소를 보였으며 geranium을 노출시켰을 때에도 유사한 경향을 보였다. 따라서 eucalyptus나 geranium를 생체에 적용할 때 저농도하에서 T세포 증식을 포함하는 IL-2 관여 면역반응이 증강될 것으로 보인다. 비장세포에서 IL-4의 생성은 eucalyptus 고농도에서 증가를 보이지만 저농도에서는 큰 변화를 보이지 않았으며 geranium의 경우는 농도 의존적으로 증가하는 양상을 보였다. 따라서 eucalyptus나 geranium을 생체에 적용하였을 때 IL-4 증가는 B세포 증식을 포함하는 IL-4관련 여러 가지 면역반응을 상향시킬 것으로 예상된다.

Keywords

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