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The Pharmaceutical Society of Korea (대한약학회)
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Guaiane Sesquiterpenoids from Torilis japonica and Their Cytotoxic Effects on Human Cancer Cell Lines

  • Park Hye Won (College of Pharmacy, Woosuk University) ;
  • Choi Sang-Un (Korea Research Institute of Chemical Technology) ;
  • Baek Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center) ;
  • Kim Sung-Hoon (Graduate School of East-West Medical Science, KyungHee University) ;
  • Eun Jae Soon (College of Pharmacy, Woosuk University) ;
  • Yang Jae Heon (College of Pharmacy, Woosuk University) ;
  • Kim Dae Keun (College of Pharmacy, Woosuk University)
  • Published : 2006.02.01
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Abstract

A new compound 2 and two known guaiane-type sesquiterpenoids were isolated from the methylene chloride-soluble fraction of the methanolic extract of the fruits of Torilis japonica (Umbelliferae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as torilin (1), 11-acetoxy-8-angeloyloxy-$1{\beta}$-hydroxy-4-guaien-3-one ($1{\beta}$-hydroxytorilin, 2), and 11-acetoxy-8-angeloyloxy-$1{\alpha}$-hydroxy-4-guaien-3-one ($1{\alpha}$-hydroxytorilin, 3) by spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.

Keywords

References

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