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Guaiane Sesquiterpenoids from Torilis japonica and Their Cytotoxic Effects on Human Cancer Cell Lines  

Park Hye Won (College of Pharmacy, Woosuk University)
Choi Sang-Un (Korea Research Institute of Chemical Technology)
Baek Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center)
Kim Sung-Hoon (Graduate School of East-West Medical Science, KyungHee University)
Eun Jae Soon (College of Pharmacy, Woosuk University)
Yang Jae Heon (College of Pharmacy, Woosuk University)
Kim Dae Keun (College of Pharmacy, Woosuk University)
Publication Information
Archives of Pharmacal Research / v.29, no.2, 2006 , pp. 131-134 More about this Journal
Abstract
A new compound 2 and two known guaiane-type sesquiterpenoids were isolated from the methylene chloride-soluble fraction of the methanolic extract of the fruits of Torilis japonica (Umbelliferae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as torilin (1), 11-acetoxy-8-angeloyloxy-$1{\beta}$-hydroxy-4-guaien-3-one ($1{\beta}$-hydroxytorilin, 2), and 11-acetoxy-8-angeloyloxy-$1{\alpha}$-hydroxy-4-guaien-3-one ($1{\alpha}$-hydroxytorilin, 3) by spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
Keywords
Torilis japonica; Umbelliferae; Sesquiterpenoid; 1-Hydroxytorilin;
Citations & Related Records

Times Cited By Web Of Science : 10  (Related Records In Web of Science)
Times Cited By SCOPUS : 9
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