A Study on Surface Characteristics and Stability of Implants Treated with Anodic Oxidation and Fluoride Incorporation

양극 산화와 불소 화합물로 처리한 임플랜트의 표면 특성 및 골유착 안정성에 관한 연구

  • Lim, Jae-Bin (Department of Prosthodontics, College of Dentistry, Dankook University) ;
  • Cho, In-Ho (Department of Prosthodontics, College of Dentistry, Dankook University)
  • 임재빈 (단국대학교 치과대학 치과보철학교실) ;
  • 조인호 (단국대학교 치과대학 치과보철학교실)
  • Published : 2006.12.30

Abstract

State of problem : A number of investigation about increase of surface area via various surface treatments and modification of surface constituent have been carried out. Purpose : The surface characteristics and stability of implants treated with anodic oxidation, fluoride ion incorporation, and groups treated with both methods were evaluated. Material and method : Specimens were divided into six groups, group 1 was the control group with machined surface implants, groups 2 and 3 were anodic oxidized implants (group 2 was treated with 1M $H_2SO_4$ and 185V, group 3 was treated with 0.25M $H_2SO_4$ and $H_3PO_4$ and 300V). Groups 4, 5 and 6 were treated with fluoride. Group 4 was machined implants treated with 0.1% HF, and groups 5 and 6 were groups 2 and 3 treated with 10% NaF respectively. Using variable methods, implant surface characteristics were observed, and the implant stability was evaluated on rabbit tibia at 0, 4, 8 and 12 weeks. Result : 1. In comparison of the surface characteristics of anodic oxidized groups, group 2 displayed delicate and uniform oxidation layer with small pore size containing Ti, C, O and showed mainly rutile, but group 3 displayed large pore size and irregular oxidation layer with many crators. 2. In comparison of the surface characteristics of fluoride treated groups 4, 5, 6 and non-fluoride treated groups 1, 2, 3, the configurations were similar but the fluoride treated groups displayed rougher surfaces and composition analysis revealed fluoride in groups 4, 5, 6. 3. The fluoride incorporated anodic oxidized groups showed the highest resonance frequency values and removal torque values, and the values decreased in the order of anodic oxidized groups, fluoride treated group, control group. 4. According to implant stability tests, group 2 and 3 showed significantly higher values than the control group (P<.05). The fluoride treated groups showed relatively higher values than the non fluoride treated groups and there were significant difference between group 4 and group 1 (P<.05). Conclusion : From the results above, it can be considered that the anodic oxidation method is an effective method to increase initial bone stability and osseointegration and fluoride containing implant surfaces enhance new bone formation. Implants containing both of these methods should increase osseointegration, and reduce the healing period.

Keywords

Acknowledgement

Supported by : 오스템

References

  1. Branemark P-I. Osseointegration and its experimental background. J Prosthet Dent 1983; 50: 399-410 https://doi.org/10.1016/S0022-3913(83)80101-2
  2. Albrektsson T, Branemark P-I, Hasson HA, Lindstrom J. Osseointegrated titanium implants. Acta Orthp Scand 1981; 52: 155-170 https://doi.org/10.3109/17453678108991776
  3. Wennerberg A, Albrektsson T. Suggested guidelines for the topographic evaluation of implant surfaces. Int J Oral Maxillofac Implants 2000; 15: 331-344
  4. Eliades T. Passive film growth on titanium alloys : Physico-chemical and biological consideration. Int J Oral Maxillofac Implants 1997; 12: 621-627
  5. Pan J, Thierry D, Leygraf C. Electrochemical impedance spectroscopy study of the passive oxide film on titanium for implant application. Electrochim Acta 1996; 41: 1143-1153 https://doi.org/10.1016/0013-4686(95)00465-3
  6. Lausmaa J, Linder L. Surface spectroscopic characterization of titanium implants after separation from plastic-embedded tissue. Biomaterials 1988; 9: 277-280 https://doi.org/10.1016/0142-9612(88)90098-1
  7. Keller JC, Stanford CM, Wightman JP, Draughn RA, Zaharias R. Characterization of titanium implant surfaces. J Biomed Mater Res 1994; 28: 939-946 https://doi.org/10.1002/jbm.820280813
  8. Kieswetter K, Schwarz Z, Dean DD, Boyan BD. The role of implant surface characteristics in the healing of bone. Crit Rev Oral Biol Med 1996; 7: 329-345 https://doi.org/10.1177/10454411960070040301
  9. Pouilleau J, Devilliers D, Garrido F, Durand-Vidal S, Mahe E. Structure and composition of passive titanium oxide film. Mater Sci Eng 1997; 47: 235-243 https://doi.org/10.1016/S0921-5107(97)00043-3
  10. Sui YT, Johansson CB, Petronics S, Krozer A, Jeong YS, Wennerberg A, Albrektsson T. Characteristics of the surface oxides on turned and electrochemically oxidized pure titanium implants up to dielectric breakdown the oxide thickness, micropore configurations, surface roughness, crystal structure and chemical composition. Biomaterials 2002; 23: 491-501 https://doi.org/10.1016/S0142-9612(01)00131-4
  11. Choi JW, Kim KN, Heo SJ, Chang IT, Han JH, Baik HK, Choi YC, Wennerberg A. The effects of various surface treatment methods on the osseointegration. J Korean Acad Prosthodont 2001; 39: 71-83
  12. Ivanoff CJ, Widmark G, Johanssen C, Wennerberg A. Histologic evaluation of bone response to oxidized and turned titanium micro-implnants in human jaw bone. Int J Oral Maxillofac Implants 2003; 18: 341-348
  13. Sui YT, Johansson CB, Jeong Y, Roser K, Wennerberg A, Albrektsson T. Oxidized implants and their influence on the bone response. J Mater Sci Mater Med 2001; 12: 1025-1031 https://doi.org/10.1023/A:1012837905910
  14. Sul YT, Johansson CB, Jeong Y, Wennerberg A, Albrektsson T. Resonance frequency and removal torque analysis of implants with turned and anodized surface oxides. Clin Oral Implants Res 2002; 13: 252-259 https://doi.org/10.1034/j.1600-0501.2002.130304.x
  15. Ishizawa H, Ogino M. Characterization of thin hydroxyapatite layers formed on anodic titanium oxide films containing Ca and P by hydrothermal treatment. J Biomed Mater Res 1995; 29: 1071-1079 https://doi.org/10.1002/jbm.820290907
  16. Li LH, Kong YM, Kim HW, Kim YW, Kim HE, Heo SJ, Koak JY. Improved biological performance of Ti implants due to surface modification by micro-arc oxidation. Biomaterials 2004; 25: 2867-2876 https://doi.org/10.1016/j.biomaterials.2003.09.048
  17. Yang B, Uchida M, Kim HM, Zhang X, Kokubo T. Preparation of bioactive metal via anodic oxidation treatment. Biomaterials 2004; 25: 1003-1010 https://doi.org/10.1016/S0142-9612(03)00626-4
  18. Cho DH, Lim JH. A study on the surface roughness and initial stability of various dental implants. J Korean Acad Stomatognathic Function and Occlusion 2000; 16: 197-210
  19. Kang BS, Cho IH. A histomorphometric and stability of two kinds of implants with different surface roughness. J Korean Acad Oral Maxillofac Implants 2001; 5: 42-69
  20. Wong M, Eulenberger J, Schenk R, Hunziker E. Effect of surface topography on the osseointegration of implant materials in trabecular bone. J Biomed Mater Res 1995; 29: 1567-1575 https://doi.org/10.1002/jbm.820291213
  21. Ungersbock A, Pohler O, Perren SM. Evaluation of the soft tissue interface at titaniwn implants with different surface treatments : experimental study on rabbits. Biomed Mater Eng 1994; 4: 317-325
  22. Sul YT, Johansson CB, Wennerberg A, Cho LR, Chang BS, Albrektsson T. Optimal surface proporties of oxidized implants for reinforcement of osseointegration : surface chemistry, oxide thickness, porosity, roughness, and crystal structure. Int J Oral Maxillofac Implants 2005; 20: 349-359
  23. De Maeztu MA, Alava JI, Gay-Escoda C. Ion implantation: Surface treatment for improving the bone integration of titanium and Ti6A14V dental implants. Clin Oral Implants Res 2003; 14: 57-62 https://doi.org/10.1034/j.1600-0501.2003.140108.x
  24. Sul YT, Byon ES, Jeong Y. Biochemical measurements of calcium-incorporated oxidized implants in rabbit bone: effect of calcium surface chemistry of a novel implant. Clin Implant Dent Relat Res 2004; 6: 101-110 https://doi.org/10.1111/j.1708-8208.2004.tb00032.x
  25. Ellingsen JE, Johansson CB, Wennerberg A, Holmen A. Improved retention and bone-to-implant contact with fluoride-modified titanium implants. Int J Oral Maxillofac Implants 2004; 19: 659-666
  26. Ellingsen JE. On the properties of surface-modified titanium. In: Davies JE(ed). Bone Engineering. Toronto: EmSquared, 2000; 183-189
  27. Gedalia I, Zipkin I. The role of fluoride in bone structure. St. Louis: Warren H. Green, 1973
  28. Ellingsen JE. Pre-treatment of titanium implants with fluoride improves their retention in bone. J Mater Sci Mater Med 1995; 6: 749-753 https://doi.org/10.1007/BF00134312
  29. Shteyer A, Liberman R, Simkin A. Gedalia I. Effect of local application of fluoride on healing of experimental bone fractures in rabbits. Calcif Tissue Res 1977; 22: 297-302 https://doi.org/10.1007/BF02010368
  30. Kasemo B, Lausmaa J. Biomaterials and implant surfaces; A surface science approach. Int J Oral Maxillofac Implants 1988; 3: 247-259
  31. Larsson C, Thomsen P, Aronsson BO, Rodahl M, Lausmaa J. Bone response to surface modified titanium implants with different oxide thickness and morphology. Biomaterials 1994; 15: 1062-1074 https://doi.org/10.1016/0142-9612(94)90092-2
  32. Lim YJ, Oshida Y, Andres CJ, Barco MT. Surface characterizations of variously treated titanium materials. Int J Oral Maxillofac Implants 2001; 16: 333-342
  33. Buser D, Schenk RK, Steinmann S, Fiorollini JP, Fox CH, Stich H. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature. J Biomed Mater Res 1991; 25: 889-902 https://doi.org/10.1002/jbm.820250708
  34. Taylor GC, Waddington RJ, Moseley R, Williams KR, Embery G. Influence of titanium oxide and titanium peroxy gel on the breakdown of hyaluronan by reactive oxygen species. Biomaterials 1996; 13: 1313-1319
  35. Lee SH, Cho IH. Surface characteristics and bioactivity of anodically oxidized titanium surfaces. Ph.D Thesis in 2004; College of Dentistry, Dankook University, Korea
  36. Bosetti M, Masse A, Tobin E, Cannas M. In vivo evaluation of bone tissue behavior on ion implanted surfaces. J Mater Sci Mater Med 2001; 12: 431-435 https://doi.org/10.1023/A:1011253121063
  37. Nishiguchi S, Kato H, Hujita H, Oka M, Kim HM, Kokubo T. Titanium metals form direct bonding to bone after alkali and heat treatments, Biomaterials 2001; 22: 2525-2533 https://doi.org/10.1016/S0142-9612(00)00443-9
  38. Kim HM. Ceramic bioactivity and related biomimetic strategy. Current Opinion in Solid State and Materials Science 2003; 7: 289-299 https://doi.org/10.1016/j.cossms.2003.09.014
  39. Kokubo T, Kim HM, Kawashita M, Nakamura T. Bioactive metals: preparation and properties. J Mater Sci Mater Med 2004; 15: 99-107 https://doi.org/10.1023/B:JMSM.0000011809.36275.0c
  40. Uchida M, Kim HM, Kokubo T, Fujibayashi S, Nakamura T. Structural dependence of apatite formation on titania gels in a simulated body fluid. J Biomed Mater Res 2003; 64: 164-170
  41. Hero H, Wie H, Jorgensen RB, Ruyter IE. Hydroxyapatite coating on Ti produced by hot isostatic pressing. J Biomed Mater Res 1994 Mar; 28: 343-348 https://doi.org/10.1002/jbm.820280308
  42. Savarino L, Fini M, Ciapetti G, Cenni E, Granchi D, Baldimi N, Greco M, Rizzi G, Giardino R, Giunti A. Biologic effects of surface roughness and fluorhydroxyapatite coating on osteointegration in external fixation systems : an in vivo experimental study. J Biomed Mater Res A 2003; 66: 652-662