The Korean Journal of Pain

  • 제19권2호
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  • Pages.142-145
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  • 2006
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  • 2005-9159(pISSN)
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  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
권호 표지

흰쥐의 포르말린시험에서 복강 내로 투여한 비선택적 산화질소합성효소 억제제의 항통각효과

The Antinociceptive Effect of Intraperitoneally Administered Nonselective Nitric Oxide Synthase Inhibitor on the Rat Formalin Test

  • 오민혜 (충남대학교 의과대학 마취통증의학교실) ;
  • 이원형 (충남대학교 의과대학 마취통증의학교실) ;
  • 고영권 (충남대학교 의과대학 마취통증의학교실)
  • Oh, Minhye (Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University) ;
  • Lee, Wonhyung (Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University) ;
  • Go, Youngkwon (Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University)
  • 투고 : 2006.08.04
  • 심사 : 2006.10.09
  • 발행 : 2006.12.30
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초록

Background: Nitric oxide (NO) is involved in the transmission and modulation of nociceptive information at the peripheral, spinal cord and supraspinal levels. We conducted this experiment to assess the antinociceptive effects of a nonselective nitric oxide synthase (NOS) inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on the modulation of pain in rats subjected to the formalin test. Methods: Formalin 5% was injected in the right hind paw after intraperitoneal (IP) injection of various doses of L-NAME (0.5 mg/kg, 1.5 mg/kg with and without L-arginine 100 mg/kg, 5.0 mg/kg). The number of flinches was measured. Results: Formalin injected into the rat hind paw induced a biphasic nociceptive behavior. IP injected L-NAME diminished the nociceptive behaviors in a dose-dependent manner during phases 1 and 2. The concomitant injection of L-arginine reversed the antinocipetive effect of L-NAME. Conclusions: The data demonstrates that a nonselective NOS inhibitor, L-NAME, possesses antinociceptive properties in rats subjected to the formalin test, and the antinociceptive effect of L-NAME is reversed by the concomitant administration of L-arginine.

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참고문헌

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