The Korean Journal of Pain

  • 제19권2호
  • /
  • Pages.137-141
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  • 2006
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  • 2005-9159(pISSN)
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  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
권호 표지

포르말린 및 열성 자극 유발 통증에 대한 척수강 Melatonin의 항침해 효과

Antinociceptive Effects of Intrathecal Melatonin on Formalin- and Thermal-induced Pain in Rats

  • 정성태 (충남대학교 의과대학 마취통증의학교실) ;
  • 진원종 (충남대학교 의과대학 마취통증의학교실) ;
  • 배홍범 (충남대학교 의과대학 마취통증의학교실) ;
  • 김석재 (충남대학교 의과대학 마취통증의학교실) ;
  • 최정일 (충남대학교 의과대학 마취통증의학교실) ;
  • 강명우 (충남대학교 의과대학 마취통증의학교실) ;
  • 정창영 (충남대학교 의과대학 마취통증의학교실) ;
  • 윤명하 (충남대학교 의과대학 마취통증의학교실)
  • Chung, Sung Tae (Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Jin, Won Jong (Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Bae, Hong Beom (Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Kim, Seok Jai (Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Choi, Jeong Il (Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Kang, Myung Woo (Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Jeong, Chang Young (Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Yoon, Myung Ha (Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School)
  • 투고 : 2006.07.12
  • 심사 : 2006.09.21
  • 발행 : 2006.12.30
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초록

Background: It has been known that melatonin is involved in the modulation of nociceptive transmission. However, the effect of melatonin administered spinally has not been examined. Therefore, we examined the effect of melatonin on the formalin-induced or thermal-induced nociception at the spinal level. Methods: Intrathecal catheter was inserted into the subarachnoid space of male Sprague-Dawley rats. Pain was assessed by formalin test (induced by injection of $50{\mu}l$ of a 5% formalin solution to the hindpaw) or Hot-Box test (induced by radiant heat application to the hindpaw). The effect of intrathecal melatonin was examined on flinching behavior in the formalin test or withdrawal response in Hot-Box test. Results: Intrathecal melatonin produced a limited, but dose-dependent reduction of the flinching response during phase 1 and 2 in the formalin test. In addition, melatonin delivered at evening also decreased the flinching response in both phases of the formalin test. Melatonin restrictively increased the withdrawal latency in Hot-Box test. Conclusions: These results suggest that melatonin is active against the formalin- and thermal-induced nocicpetion at the spinal level, but the effect is limited.

키워드

과제정보

연구 과제 주관 기관 : 전남대학교병원

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