Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
권호 표지

Formation of a New Solo-LTR of the Human Endogenous Retrovirus H Family in Human Chromosome 21

  • Huh, Jae-Won (Division of Biological Sciences, College of Natural Sciences, Pusan National University) ;
  • Kim, Dae-Soo (PBBRC, Interdisciplinary Research Program of Bioinformatics, Pusan National University) ;
  • Ha, Hong-Seok (Division of Biological Sciences, College of Natural Sciences, Pusan National University) ;
  • Kim, Tae-Hong (Division of Biological Sciences, College of Natural Sciences, Pusan National University) ;
  • Kim, Wook (Department of Biological Sciences, Dankook University) ;
  • Kim, Heui-Soo (Division of Biological Sciences, College of Natural Sciences, Pusan National University)
  • Received : 2006.07.04
  • Accepted : 2006.09.27
  • Published : 2006.12.31
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Abstract

Human endogenous retroviruses (HERVs) contribute to various kinds of genomic instability via rearrangement and retrotransposition events. In the present study the formation of a new human-specific solo-LTR belonging to the HERV-H family (AP001667; chromosome 21q21) was detected by a comparative analysis of human chromosome 21 and chimpanzee chromosome 22. The solo-LTR was formed as a result of an equal homologous recombination excision event. Several evolutionary processes have occurred at this locus during primate evolution, indicating that mammalian-wide interspersed repeat (MIR) and full-length HERV-H elements integrated into hominoid genomes after the divergence of Old World monkeys and hominoids, and that the solo-LTR element was created by recombination excision of the HERV-H only in the human genome.

Keywords

Acknowledgement

Supported by : Pusan National University

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