Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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The Clinical Efficiency of Clomiphene Citrate vs Clomiphene Citrate/GnRH Antagonist on Infertile Women with Normal Ovulatory Cycles

정상 배란주기의 불임 여성에서 Clomiphene Citrate 단독 사용과 GnRH Antagonist 병합 요법의 임상적 효용성에 관한 연구

  • Lee, Woo Seok (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University) ;
  • Sang, Jae Hong (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University) ;
  • Kim, Jae Joon (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University) ;
  • Kim, Gwang June (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University) ;
  • Kim, Dong Ho (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University) ;
  • Lee, Sang Hun (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University)
  • 이우석 (중앙대학교 부속병원 산부인과학교실) ;
  • 상재홍 (중앙대학교 부속병원 산부인과학교실) ;
  • 김재준 (중앙대학교 부속병원 산부인과학교실) ;
  • 김광준 (중앙대학교 부속병원 산부인과학교실) ;
  • 김동호 (중앙대학교 부속병원 산부인과학교실) ;
  • 이상훈 (중앙대학교 부속병원 산부인과학교실)
  • Published : 2006.09.30
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Abstract

Objective: This study was to investigate the clinical efficiency of clomiphene citrate/GnRH antagonist protocol comparing with the clomiphene citrate only protocol in infertile women with normal ovulatory cycles. Method: Among 116 patients, 43 were received assisted reproductive technologies using natural ovulatory cycle, 38 and 35 were received clomiphene citrate only protocol and clomiphene citrate/GnRH antagonist combined protocol, respectively, and the clinical results were compared and analyzed Results: In each group, basal levels of LH, FSH, $E_2$ and FSH, $E_2$ on hCG day injected were not different, but LH level and endometrial thickness on hCG injected day were decreased significantly and the pregnancy rate was increased significantly in clomiphene citrate/GnRH antagonist group. Conclusion: The pregnancy rate was increased significantly in clomiphene citrate/GnRH antagonist group compared with natural ovulatory cycle and clomiphene citrate only group.

목 적: 본 연구는 인공 수정 시술에 있어서 정상 배란주기의 여성에서 clomiphene citrate와 GnRH antagonist를 병합하여 임선을 시도한 방법을 기존의 clomiphene citrate 단독으로 사용한 방법과 비교하여 그 임상적 유용성을 알아보고자 하였다. 연구방법: 116명의 환자들 중 43명에게는 자연 배란주기를 이용하여 인공 수정 시술을 시행하였고, 38명과 35명에게 각각 clomiphene citrate 단독 요법과 clomiphene citrate와 GnRH antagonist 병합 요법으로 인공 수정 시술을 시행하여 그 임상 결과를 비교 분석하였다. 결 과: 각각의 군에서 기저 LH, FSH, $E_2$와 배란 유도를 위해 hCG를 투여하는 날의 FSH, $E_2$는 차이를 보이지 않았으나 clomiphene citrate/GnRH antagonist 병합 요법군에서 hCG를 투여한 날의 LH와 자궁 내막 두께는 의미 있게 감소하였으며 유의한 임신율의 증가가 관찰되었다. 결 론: 자연 배란주기법군, clomiphene citrate 단독 요법 사용군에 비해 clomiphene citrate/GnRH antagonist 병합 요법 사용군에서 유의하게 임신율의 향상을 나타냈다.

Keywords

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