Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Trial of Mycophenolate Mofetil Treatment on Necrotizing Meningoencephalitis in a Yorkshire Terrier Dog

요크셔 테리어 견에서 발생한 괴사성 수막뇌염을 Mycophenolate Mofetile로 치료 시도한 증례

  • Jeon, Hyo-Won (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Park, Chul (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Jung, Dong-In (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Kang, Byeong-Teck (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Kim, Ha-Jung (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Kim, Ju-Won (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Lim, Chae-Young (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Ko, Ki-Jin (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Lee, So-Young (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Cho, Sue-Kyung (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Gu, Su-Hyun (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Heo, Ra-Young (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University) ;
  • Park, Hyo-Jin (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
  • 전효원 (건국대학교 수의과대학 수의내과학교실) ;
  • 박철 (건국대학교 수의과대학 수의내과학교실) ;
  • 정동인 (건국대학교 수의과대학 수의내과학교실) ;
  • 강병택 (건국대학교 수의과대학 수의내과학교실) ;
  • 김하정 (건국대학교 수의과대학 수의내과학교실) ;
  • 김주원 (건국대학교 수의과대학 수의내과학교실) ;
  • 임채영 (건국대학교 수의과대학 수의내과학교실) ;
  • 고기진 (건국대학교 수의과대학 수의내과학교실) ;
  • ;
  • 조수경 (건국대학교 수의과대학 수의내과학교실) ;
  • 구수현 (건국대학교 수의과대학 수의내과학교실) ;
  • 허라영 (건국대학교 수의과대학 수의내과학교실) ;
  • 박효진 (건국대학교 수의과대학 수의내과학교실)
  • Published : 2006.09.30
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Abstract

A 5-year-old, male Yorkshire terrier dog was presented with progressive seizure and anorexia. Definitive diagnosis of necrotizing meningoencephalitis(NME) was made based on characteristic clinical features, brain lesion with MRI, and histopathologic examination. The dog was treated with prednisolone for 20 days, firstly. Prednisolone and mycophenolate mofetil(MMF) were then administered for 40 days following the initial therapy. However, the clinical signs were not improved and seizure frequency was increased. This patient survived around 2 months after diagnosis. This case report described the clinical findings, imaging characteristics and pathologic features of NME in a Yorkshire terrier with trial treatment using MMF.

5년령의 수컷 요크셔테리어 견이 진행성의 발작과 식욕부진으로 내원하였다. 임상증상, MRI에서의 뇌병변, 조직병리학적 검사로 괴사성 수막뇌염(NME)으로 확진되었다. 이 환견은 20일동안 프레드니솔론으로 치료되었다. 그리고 이후 40일 동안은 프레드니솔론과 mycophenolate mofetil(MMF)혼합하여 치료되었다. 하지만 임상증상은 개선되지 않았고 발작의 빈도도 증가하였다. 이 환견은 진단후 2달 동안 생존하였다. 이번 증례보고는 괴사성 수막뇌염의 임상 증상, 영상학적 특성, 조직학적 특성을 묘사하였다. 게다가 괴사성 수막뇌염에 걸린 요크셔테리어 견에서 MMF를 이용한 치료를 시도한 최초 보고이다.

Keywords

References

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