Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Inherited Malignant Ventricular Tachyarrhythmia in a German Shepherd

져먼 셰퍼드종 개에서 발생한 유전성 악성 심실성 부정맥증

  • Lee, Joon-Seok (Section of Internal Medicine, School of Veterinary Medicine, Kangwon National University) ;
  • Lee, Seung-Gon (Section of Internal Medicine, School of Veterinary Medicine, Kangwon National University) ;
  • Park, In-Chul (Section of Diagnostic Imaging, School of Veterinary Medicine, Kangwon National University) ;
  • Hyun, Chang-Baig (Section of Internal Medicine, School of Veterinary Medicine, Kangwon National University)
  • 이준석 (강원대학교 수의(학부)대학 소동물 내과교실) ;
  • 이승곤 (강원대학교 수의(학부)대학 소동물 내과교실) ;
  • 박인철 (강원대학교 수의(학부)대학 방사선 교실) ;
  • 현창백 (강원대학교 수의(학부)대학 소동물 내과교실)
  • Published : 2006.09.30
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Abstract

A 9-month-old neutered male German Shepherd dog was referred with the primary complaint of episodic collapse. Apparent abnormal findings were not observed in physical examination, routine biochemistry, and diagnostic imaging studies. In the 12-lead surface ECG after collapse, the dog showed frequent ventricular premature contractions (VPCs) with torsade de pointes. The frequency of VPCs was reduced after lidocaine infusion. Based on the history, findings in event recordings oi the ECG and lidocaine response test, the dog was diagnosed as inherited malignant ventricular tachyarrhythmia. Although the dog was initially responded to oral sotalol therapy, the dog was died suddenly. This report described the first case of malignant ventricular tachyarrhythmia of German Sheperd in Korea.

9살령 수컷 져먼 세퍼드종 개가 주기적인 실신 증상으로 내원하였다. 신체 검사, 혈액 생화학 검사 및 진단영상학 검사에서 특별한 이상 소견은 관찰되지 않았다. 실신 직후 실시한 12-lead심전도에서 환견은 심실조기박동을 동반한 악성 심실성 빈맥(torsade depointes)소견이 관찰되었다. Lidocaine정맥주사 후 심실성 부정맥의 빈도수는 감소되었다. 병력과 심전도 검사(event recordings)를 토대로 본 증례를 져먼 세퍼드종의 유전성 심실성 부정맥증으로 진단하였다. 환견은 초기에 sotalol 구강투여로 증상이 개선되었지만 한달 후 특별한 증상 없이 급사하였다. 본 증례는 국내에서 최초로 보고된 유전성 악성 심실성 부정맥증이다.

Keywords

References

  1. Dae MW, Lee RJ, Ursell PC, Chin MC, Stillson CA, Moise NS. Heterogeneous sympathetic innervation in German shepherd dogs with inherited ventricular arrhythmia and sudden cardiac death. Circulation 1997; 96: 1337-1342 https://doi.org/10.1161/01.CIR.96.4.1337
  2. Hyun C. Molecular genetics of inherited cardiac conduction defects in humans and dogs. J Vet Clin 2004; 21: 219-228
  3. Hyun C, Filippich LJ. Molecular genetics on sudden cardiac death in small animals. Vet J 2006; 171: 39-50 https://doi.org/10.1016/j.tvjl.2004.10.022
  4. Meurs KM, Apier AW, Wright NA, Atkins CE, DeFrancesco TC, Gordon SG, Hamlin RL, Keene BW, Miller MW, Moise NS. Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers. J Am Vet Med Assoc 2002; 221: 522-527 https://doi.org/10.2460/javma.2002.221.522
  5. Moise NS, Meyers-Wallen V, Flahive WJ, Valentine BA, Scarlett JM, Brown CA, Chavkin MJ, Dugger DA, Renaud-Farrell S, Kornreich B. Inherited ventricular arrhythmias and sudden death in German shepherd dogs. J Am Coll Cardiol 1994; 24: 233-243 https://doi.org/10.1016/0735-1097(94)90568-1
  6. Moise NS, Gilmour RF, Riccio ML, Flahive WF. Diagnosis of inherited ventricular tachycardia in German shepherd dogs. J Am Vet Med Assoc 1997; 210: 403-410
  7. Moise, NS. From cell to cageside cardiac rhythms in the dog: autonomic influence. J Small Anim Pract 1998; 39: 460-468 https://doi.org/10.1111/j.1748-5827.1998.tb03680.x
  8. Moise, NS. Diagnosis and management of canine arrhythmias. In: Fox PR, Sisson DD, Moise NS (eds) Canine and Feline Cardiology, 2nd ed. Philadelphia: W. B. Saunders 1999; 331-385
  9. Moise NS. Inherited arrhythmias in the dog: potential experimental models of cardiac disease. Cardiovascular Research 1999; 44: 37-46 https://doi.org/10.1016/S0008-6363(99)00198-4
  10. Moise, NS. Chronic Management of Tachyarrhythmias in the Dog. In: Proceedings of $26^{th}$ Waltham/OSU symposium. Small Animal Cardiology 2002; 1-10
  11. Obreztchikova MN, Sosunov EA, Anyukhovsky EP, Moise NS, Robinson RB, Rosen MR. Heterogeneous ventricular repolarization provides a substrate for arrhythmias in a German shepherd model of spontaneous arrhythmic death. Circulation 2003; 108: 1389-1394 https://doi.org/10.1161/01.CIR.0000086461.86642.22
  12. Sosunov EA, Obreztchikova MN, Anyukhovsky EP, Moise NS, Danilo P, Robinson RB, Rosen MR. Mechanisms of alpha-adrenergic potentiation of ventricular arrhythmias in dogs with inherited arrhythmic sudden death. Cardiovasc Res 2004; 61: 715-723 https://doi.org/10.1016/j.cardiores.2003.12.025