Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Treatment of Meningitis Caused by Vancomycin-Resistant Enterococcus with Synercid

  • Oh, Hyung-Suk (Department of Neurosurgery, Kosin University College of Medicine) ;
  • Jeon, Byung-Chan (Department of Neurosurgery, Kosin University College of Medicine) ;
  • Kim, Young-Su (Department of Neurosurgery, Kosin University College of Medicine) ;
  • Chun, Tae-Sang (Department of Neurosurgery, Kosin University College of Medicine)
  • Published : 2006.02.28
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Abstract

Vancomycin-resistant enterococci[VRE] are rare cause of meningitis, occurring in immunocompromised patients, severely ill, hospitalized patient, and patients who have undergone neurosurgical procedures. Resistance to vancomycin has increased in frequency during the past few years. Limited therapeutic options are available for VRE infectionsandtheoptimumtherapy has not been established. We report a case of VRE meningitis that was successfully treated with administration of quinupristin-dalfopristin [Synercid] by both intravenous and intraventricular routes. A brief review of the literature is provided, which indicates that optimal management with Synercid should include daily intraventricular doses of at least 2mg and intravenous 0.5mg/kg every 8 hours. We also review the previously reported cases of VRE meningitis.

Keywords

References

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