Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
권호 표지

General Pharmacological Study of GCSB-5, a Herbal Formulation

  • Published : 2006.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

The general pharmacological properties of GCSB-5, a herbal formulation consisting of 6 Oriental herbs(Ledebouriellae Radix, Achyranthis Radix, Acanthopanacis Cortex, Cibotii Rhizoma, Glycine Semen and Eucommiae Cortex), were investigated in mice, rats, guinea pigs and rabbits. The administration of GCSB-5 had no effect on general behavior, and did not influence the central nervous system. Mean blood pressure, heat1 and respiratory rate and contractile response of the isolated guinea pig atrium were unaffected by the treatment of GCSB-5. Addition of GCSB-5 did not cause spontaneous relaxation and contraction of the isolated guinea pig ileum and rat uterus. And also, GCSB-5 had no effect on the gastrointestinal system and the blood system of the animals examined in this study. GCSB-5, at higher doses(1,000 and 3,000 mg/kg), increased the urinary excretion of electrolytes, however, the urine volume and pH in rats were unaffected. Taken together, these results indicate that GCSB-5 does not induce any adverse effects in experimental animals and is expected to have no significant general pharmacological activities.

Keywords

References

  1. Ahn, Y.R., Kim. H.S. and Park, J.S. (1978) A pharmacological study of diuretic medicinal plants. Kor. J. Phannacogn. 9, 99-102
  2. Araki, S. and Ueki, S. (1972) Changes in sensitivity to convulsion in mice with olfactory bulb ablation. Jap. J. pharmacol. 22, 447-456 https://doi.org/10.1254/jjp.22.447
  3. Dunham, N.W., Miya, T.S. and Edwards, C.D. (1957) Pharmacological activity of a series of basic esters mono- and dialkyl malonic acid. J. Am. Pharm. Assoc. 46, 209-288 https://doi.org/10.1002/jps.3030460323
  4. Elliott, A.M., Smith, B.H., Penny, K.I., Smith, W.C. and Chambers, W.A. (1999) The epidemiology of chronic pain in the community. Lancet 354, 1248-1252 https://doi.org/10.1016/S0140-6736(99)03057-3
  5. Irwin, S. (1968) Comprehensive observational assessment: Ia. A systematic quantitative procedure for assessing the behavioral physiologic state of the mouse. Psychophannacologia 12, 222-257
  6. Kim, S.H., Lee, C.H., Lee, J.S., Cho, K.H., Kim, S.O., Cho, S.H., Cho, H.K. and Lee, S.M. (2005) Anti-Inflammatory Activities of a Herbal Preparation GCSB-5 on Acute and Chronic Inflammation. Kor. J. Phannacogn. 36, 311-317
  7. Lee, C.H., Kim, S.H., Lee, J.S., Cho, K.H., Kim, J.S., Cho, S.H. and Lee, S.M. (2005) Evaluation of the Antinociceptive Properties of GCSB-5, a Herbal Formulation. Kor. J. Pharmacogn. 36, 299-304
  8. Rang, H.P. (1964) Stimulant actions of volatile anesthetics on smooth muscle. Br. J. Pharmacol. 27, 256-375
  9. Shay, H., Sun, D.C. and Gruenstein, M. (1954) A quantitative method for measuring spontaneous gastric secretion in the rat. Gastroenterology 26, 906-913
  10. Silverstein, F.E., Faich, G., Goldstein, J.L., Simon, L.S., Pincus, T., Whelton, A., Makuch, R., Eisen, G., Agrawal, N.M., Stenson, W.F., Burr, A.M., Zhao, W.W., Kent, J.D., Lefkowith, J.B., Verburg, K.M. and Geis, G.S. (2000) Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA 284, 1247-1255 https://doi.org/10.1001/jama.284.10.1247
  11. Swinyard, E.A., Brow, W.C. and Goodman, L.S. (1952) Comparative assays of antiepileptic drugs in mice and rats. J. Pharmacol. Exp. Ther. 106, 319-330
  12. Takagi, K. and Lee, E.B. (1972) Pharmacological studies on Platycodon grandiflorum A De. III. Activities of crude platycodin on respiratory and circulatory systems and its other pharmacological activities. Yakugaku Zasshi 92, 969-973 https://doi.org/10.1248/yakushi1947.92.8_969
  13. Takemori, A.E., Kupferberg, H.T. and Miller, J.W. (1969) Quantitative studies of the antagonism of morphine by nalorphine and naloxone. J. Phannacol. Exp. Ther. 169, 39-45