Fisheries and Aquatic Sciences

한국수산과학회 (The Korean Society of Fisheries and Aquatic Science)
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Coupling of ent-Cyclic Peroxide and Ircinol A, Two Biologically Active Natural Marine Products

  • Lim, Chi-Won (Biotechnology Research Center, National Fisheries R&D Institute) ;
  • Kim, Yeun-Kye (Biotechnology Research Center, National Fisheries R&D Institute) ;
  • Jang, Mi-Soon (Biotechnology Research Center, National Fisheries R&D Institute) ;
  • Park, Jin-Il (Biotechnology Research Center, National Fisheries R&D Institute) ;
  • Park, Hee-Yeun (Biotechnology Research Center, National Fisheries R&D Institute)
  • 발행 : 2006.12.30
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초록

An acidic ent-cyclic peroxide was isolated from a sponge, Plakotis sp., and showed activity against leishmaniasis and pathogenic fungi. To improve the activity of this compound, we coupled the acidic ent-cyclic at the C1 position of ircinol A. Compound 3 exhibited significant activity against Leishmania mexican a and fungi with $IC_{50}$ values of 0.7 and $0.3-34{\mu}g/mL$, respectively. The yield of compound 3 was 98%.

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참고문헌

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피인용 문헌

  1. Chemistry and Selective Tumor Cell Growth Inhibitory Activity of Polyketides from the South China Sea Sponge Plakortis sp. vol.15, pp.5, 2017, https://doi.org/10.3390/md15050129
  2. Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products vol.10, pp.None, 2006, https://doi.org/10.3762/bjoc.10.6