Food Science of Animal Resources (한국축산식품학회지)

Korean Society for Food Science of Animal Resources (한국축산식품학회)
권호 표지

Cholesterol Removal of Milk and Dairy Products using ${\beta}-Cyclodextrin$

${\beta}-Cyclodextrin$을 이용한 우유 및 유제품의 콜레스테롤 제거

  • Han, Eun-Mi (Department of Food Science and Technology, Sejong University) ;
  • Kim, Song-Hee (Department of Food Science and Technology, Sejong University) ;
  • Kwak, Hae-Soo (Department of Food Science and Technology, Sejong University)
  • Published : 2006.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

This review highlights areas of interest in the cholesterol removal of milk and dairy products. The demand for cholesterol removal has increased due to consumer demand for cholesterol-reduced products. At present the best method for producing without changing flavor, taste and texture of the products is entrapping cholesterol by ${\beta}-cyclodextrin({\beta}-CD)$. Especially, crosslinking of ${\beta}-CD$ is important due to recycling that could be separated the ${\beta}-CD$ from treated cream or milk. The recycling can be up to 10 times with keeping the rate of cholesterol removal. Various functional milk and dairy products can be produced in this manner. This report reviews general information including methods of cholesterol removal, crosslinking of ${\beta}-CD$, and recycling of the ${\beta}-CD$ in milk and dairy products.

Keywords

References

  1. Ahn, J. and Kwak, H. S. (1999) Optimizing cholesterol removal in cream using ${\beta}-cyclodextrin$ and response surface methodology. J. Food Sci. 64, 629-632 https://doi.org/10.1111/j.1365-2621.1999.tb15098.x
  2. Bea, H. Y., Kim, H. Y., Jung, T. H., and Kwak, H. S. (2006) Effects of crosslinked ${\beta}-cyclodextrin$ treatment on cholesterol removal, and chemical and sensory propeties in Feta cheese. J. Dairy Sci. 89, Suppl.1.W34
  3. Biss, K., Ho, K. J., Mikkeisn., B. B., Lowis., L., and Tayor, C. H. (1971) Some unique biological characteristics of the Maasai of east Africa. N. Engl. J. Med., 284, 694-699 https://doi.org/10.1056/NEJM197104012841304
  4. Bogin, E. (1991) Low cholesterol eggs. Proceeding of the 4th European symposium on the quality of eggs products. 97
  5. Chang, E. J., Oh, H. I., and Kwak, H. S. (2001) Optimization of cholesterol removal conditions from homogenized milk by treatment with saponin. Asian-Aust. J. Animal Sci. 14, 844-849 https://doi.org/10.5713/ajas.2001.844
  6. Chin, P. Y. and Chein, S. S. (1990) Methods of recovering and separation water-soluble cyclodextrin form cyclodextrin formation liquid. U. S Patent 4970164
  7. De Miguel, I., Rieumajou, Y., and Betbeder, D. (1999) New methods to determine the extent of reaction of epichlorohydrin with maltodextrius. Carbohydrate Research., 319, 17-23 https://doi.org/10.1016/S0008-6215(99)00108-1
  8. Glodstein, J. L. and Brown, M. S. (1977) The low-density lipoprotein pathway and its relation to atherosclerosis. Annu. Rev. Biochem. 46, 897-930 https://doi.org/10.1146/annurev.bi.46.070177.004341
  9. Han, E. M., Kim, S. H., Kim, K. W., and Kwak, H. S. (2006) Recycling efficiency of crosslinked ${\beta}-cyclodextrin$ in milk and cream. Asian-Aust. J. Anim. Sci. (submitted)
  10. Han, E. M., Kim, S. H., Ahn, J., and Kwak, H. S. (2005) Cholesteol removal from homogenized milk with crosslinked ${\beta}-cyclodextrin$ by adipic acid. Asian-Aust. J. Anim. Sci. 18, 1794-1799 https://doi.org/10.5713/ajas.2005.1794
  11. Hedges, A., Shieh W., and Ameral, R. (1993) Process for removal of residue of cyclodextrin. Austrailia Patent WO 93/24022
  12. Hwang, J. H., Lee, S. J., and Kwak, H. S. (2005) Change of properties and cholesterol lowering effect in evening primrose oil-added and cholesterol-reduced milk. AsianAust. J. Anim. Sci. 18, 1041-1047
  13. Jung, T. H., Park, H. S., and Kwak, H. S. (2005) Optimization of cholesterol removal by crosslinked ${\beta}$ -cyclodextrin in egg yolk. Food Sci. Biotechnol. 14, 793-797
  14. Jung, T. H., Kim, J. J., Yu, S. H., Ahn, J., and Kwak, H. S. (2005) Properties of cholesterol-reduced butter and effect of gamma linolenic acid added butter on blood cholesterol. Asian-Aust. J. Anim. Sci. 18, 1646-1654 https://doi.org/10.5713/ajas.2005.1646
  15. Kartha, K. P. R., and Srivastava, H. C. (1985) Reaction of epichlorohydrin with cabohydrate polymer II. Starch. 37, 297-301 https://doi.org/10.1002/star.19850370905
  16. Kim, H. S. and Lee, Y. E. (1996) Influence of crosslinking on gelatinization behavior and morphological change of potato starch. Kor. J. Food Sci. Technol. 28, 580-586
  17. Kim, H. Y., Bea, H. Y., Kim, S. Y., and Kwak, H. S. (2006) Removal of cholesterol from Blue cheese by crosslinked ${\beta}-cyclodextrin.$ J. Dairy Sci. 89, Suppl . 1 . W34
  18. Kim, J. J., Jung, T. H., Ahn, J., and Kwak, H. S. (2006) Properties of cholesterol-reduced butter made with 13 -CD and added evening primrose oil and phytosterols. J. Dairy Sei. 89, 4503-4510 https://doi.org/10.3168/jds.S0022-0302(06)72498-5
  19. Kim, J. J., Yoo, S. H., Ahn, J., Jeon, W. M., and Kwak. H. S. (2005) The effect of evening primrose oil on chemical properties and lowering blood cholesterol in nutraceutical Cheddar cheese. Arch. Pharm. Res. 19, 450-458 https://doi.org/10.1007/BF02986010
  20. Kim, S. H., Ahn, J., and Kwak, H. S. (2004) Cross linking of ${\beta}-cyclodextrin$ on cholesterol removal from milk. Arch. Pharm. Res. 27,1183-1187 https://doi.org/10.1007/BF02975126
  21. Kim, S. H., Han, E. M., Ahn, J., and Kwak, H. S. (2005) Effect of crosslinked ${\beta}-cyclodextrin$ on quality of cholesterol-reduced cream cheese. Asian-Aust. J. Anim. Sci. 18, 584-589 https://doi.org/10.5713/ajas.2005.584
  22. Kim, S. H., Kim, H. Y., and Kwak, H. S. (2006) Cholesterol removal from lard with crosslinked ${\beta}-cyclodextrin$. Asian-Aust. J. Anim. Sci. (submitted)
  23. Kobayash, S., Kainuma, K., and Suzuki, S. (1975) Cyclodextrin-production and utilization of cyclodextrin. J. Jpn. Soc. Starch Sci. 28, 132-141
  24. Kosikowski, F. V. (1990) 'Cholesterol-Free' milk and milk products : limitations in production and labeling. Food Technol. 11
  25. Kwak, H. S., Chung, C. S., and Ahn, J. (2002) Flavor compounds of cholesterol-reduced Cheddar cheese slurries. Asian-Aust. J. Anim. Sci. 15, 117-123 https://doi.org/10.5713/ajas.2002.117
  26. Kwak, H. S., lung, C. S., Seok, J. S., and Abn, J. (2003) Cholesterol removal and flavor development in Cheddar cheese. Asian-Aust. J. Anim. Sci. 16, 409-416 https://doi.org/10.5713/ajas.2003.409
  27. Kwak, H. S., Kim, S. H., Kim, J. H., Choi, H. J., and Kang, J. (2004) Immobilized ${\beta}-cyclodextrin$ as a simple and recyclable method for cholesterol removal in milk. Arch. Pharm. Res. 27, 873-877 https://doi.org/10.1007/BF02980182
  28. Kwak, H. S., Nam, C. G., and Abn, J. (2001) Low cholesterol Mozzarella cheese obtained from homogenized and ${\beta}-cyclodextrin-treated$ milk. Asian-Aust. J. Anim. Sci. 14, 268-275 https://doi.org/10.5713/ajas.2001.268
  29. Kwak, H. S., Suh, H. M., Abn, J., and Kwon, H. J. (2001) Optimization of ${\beta}-cyclodextrin$ recycling process for cholesterol removal in cream. Asian-Aust. J. Anim. Sci. 14, 548-552 https://doi.org/10.5713/ajas.2001.548
  30. Lee, D. K., Abn, J., and Kwak, H. S. (1999) Cholesterol removal from homogenized milk with ${\beta}-cyclodextrin.$ J. Dairy Sci. 82, 2327-2330 https://doi.org/10.3168/jds.S0022-0302(99)75481-0
  31. Lee, J. S., Ustunol, Z., and Smith, D. M. (1993) Cholesterol removal from cream ${\beta}-cyclodextrin$ and derivatives. J. Dairy Sci. Abs. 158
  32. Levy, R. I. (1981) Cholesterol, lipoproteins, apoproteins, and heart disease : present statusand future prospects. Clin. Chem., 27, 653-662
  33. Mentink, L., Serpelloni, M., Roquette, F. (1990) Process of refining mixture obtained from treatments of fatty media with cyclodextrin and containing complexes of cyclodextrin mainly with lipophilic substances other than fatty acids. Canadian Patent 90/01007
  34. Mun, S. H. and Shin, M. S. (2002) The effects of annealing on resistant starch content of cross-linked maize starches. Kor. J. Food Sci. Technol. 34, 431-436
  35. Nobnyuki, N. M., Mishima, Y, and Hideyuki, S. (1995) Method for recovering cyclodextrin. U. S. Patent. 544 9771
  36. Pagington, J. S. (1986) Beta-cyclodextrin. Perfumer & Flavorist
  37. Pagington, J. S. (1987) ${\beta}-cyclodextrin$(the success of molecular inclusion). J. Br. Chem. 452
  38. Pyorala, K. (1987) Dietary cholesterol in relation to plasma cholesterol and coronary heart disease. Am. J. Chem. Nutr. 45, 1176-1184 https://doi.org/10.1093/ajcn/45.5.1176
  39. Schroder, B. G. and R. J. Baer. (1990) Utilization of cholesterol-reduced milk fat in flued milks. Food Technol. 16 : 342-347
  40. Shaw, P. E., Tatum, J. H., and Wilson, C. W. (1984) Improved flavor of navel orange and grapefruit juices by removal of bitter components with ${\beta}-cyclodextrin$ polymer. J. Agric. Food Chem. 32, 832-836 https://doi.org/10.1021/jf00124a034
  41. Shim, S. Y., Ahn, J., and Kwak, H. S. (2003) Funcitional properties of cholesterol-removal whipping cream treated by ${\beta}-cyclodextrin.$ J. Dairy Sci. 86, 2767-2772 https://doi.org/10.3168/jds.S0022-0302(03)73873-9
  42. Shukla, A., Bhaskar, A. R., Rizvi, S. H., and Mulvaney, S. J. (1994) Physicochemical and rheological properties of butter made from supercritically milk fat. J. Dairy Sci. 77. 45-54 https://doi.org/10.3168/jds.S0022-0302(94)76927-7
  43. Sidhu, G. S., Oakenfull, D. G., and Rooney, M. L. (1993) Composition and method for reducing cholesterol concentration. Austrailia Pantent WO 93/05084
  44. Sieber, R. (1993) Cholesterol removal from animal food - can it be justified. Fed. Dairy Res. Inst. 45, 1243-1247
  45. Smith, D. M. and Bennink, J. L. (1995) Cholesterol reduction in liquid egg yolk using ${\beta}-cyclodextrin$ J. Food Sci. 60, 691-694 https://doi.org/10.1111/j.1365-2621.1995.tb06207.x
  46. Takahashi, K, Hattori, K, and Toda, F. (1984) Monotosylated and ${\beta}-cyclodextrin$ prepared in an alkaline aqueous solution. Tetrahedron Lett. 25, 3331-3334 https://doi.org/10.1016/S0040-4039(01)81377-0
  47. Weu, S., Timothy, C. P., and Allan, H. C. (1995) Cyclodextrin refining process. U. S. Patent 5393880
  48. Woo, K S., Hong, J. Y., and Lim, S. T. (2001) Physical properties of reversibly swellable cross-linked wheat starch. Food Eng. Prog. 5, 25-28
  49. Wurzburg, O. B. (1986) Cross-linked starches. Modified starches. 6, 41-53
  50. Yen, G. and L, Tasi (1995) Cholesterol removal from a lard-water mixture with ${\beta}-cyclodextrin.$ J. Food Sci. 60, 561-564 https://doi.org/10.1111/j.1365-2621.1995.tb09827.x
  51. 배현영 (2006) 콜레스테롤 저하 Camembert cheese 숙성 및 저장 기간 동안의 이화학적 및 관능적 특성에 관한 연구. 세종대학교 석사학위 논문