Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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A Case of Myoclonus Presenting as a Side Effect of Amitriptyline

삼환계 항우울제의 부작용으로 나타난 간대성 근경련증 1례

  • Choi, Jong-Pil (Departments of Emergency Medicine, Konyang University College of Medicine) ;
  • Park, Seong-Soo (Departments of Emergency Medicine, Konyang University College of Medicine) ;
  • Park, Joon-Seok (Departments of Emergency Medicine, Konyang University College of Medicine) ;
  • Na, Sang-Jun (Departments of Emergency Neurology, Konyang University College of Medicine)
  • 최종필 (건양대학교 의과대학 응급의학교실) ;
  • 박성수 (건양대학교 의과대학 응급의학교실) ;
  • 박준석 (건양대학교 의과대학 응급의학교실) ;
  • 나상준 (건양대학교 의과대학 신경과학교실)
  • Published : 2006.12.31
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Abstract

Myoclonus is manifested in a variety of situations including metabolic derangements, brain lesions, epilepsy, and drugs toxicity. We reported a rare case of amitriptyline-induced myoclonus. A 64-year-old man with a tension-type headache was administered amitriptyline at 15 mg/day. Eight days after initiation of amitriptyline, multifocal myoclonus developed, involving the face and upper extremities. Two hours after the administration of clonazepam at 1 mg, myoclonus resolved completely.

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