Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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A Sensorimotor Polyneuropathy Caused by Chronic Phenytoin Therapy

페니토인의 장기 복용으로 발생한 감각운동성 다발성 신경병증

  • Han, Dong-Chul (Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science) ;
  • Park, Hyeon-Mi (Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science) ;
  • Shin, Dong-Jin (Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science) ;
  • Lee, Yeong-Bae (Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science)
  • 한동철 (가천의과대학교 길병원 신경과) ;
  • 박현미 (가천의과대학교 길병원 신경과) ;
  • 신동진 (가천의과대학교 길병원 신경과) ;
  • 이영배 (가천의과대학교 길병원 신경과)
  • Published : 2006.12.31
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Abstract

Phenytoin has been used globally as an effective anticonvulsant. Among its adverse effects, peripheral neuropathy including polyneuropathy has sometimes been reported. We report a case of sensorimotor polyneuropathy associated with high serum level and long-term phenytoin therapy. A 29-year-old male presented with motor weakness in all extremities. He was treated with phenytoin (400 mg/day) for about eight years because of generalized tonic clonic seizure. During none conduction assessment, sensorimotor polyneuropathy was discovered.

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