Journal of Nutrition and Health

  • 제39권8호
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  • Pages.733-741
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  • 2006
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

칼슘과 제니스테인 섭취가 고지방식이로 유도된 비만 모델 마우스의 체지방과 지질대사에 미치는 영향

Effects of Calcium and Genistein on Body Fat and Lipid Metabolism in High Fat-induced Obese Mice

  • 김미현 (서울대학교 생활과학대학 식품영양학과, 생활과학연구소) ;
  • 김설희 (서울대학교 생활과학대학 식품영양학과, 생활과학연구소) ;
  • 박현우 (아모레퍼시픽 기술연구원 식품연구소 건강식품연구팀) ;
  • 김완기 (아모레퍼시픽 기술연구원 식품연구소 건강식품연구팀) ;
  • 이연숙 (서울대학교 생활과학대학 식품영양학과, 생활과학연구소)
  • Kim, Mi-Hyun (Department of Food & Nutrition, Research Institute of Human Ecology, Seoul Notional University) ;
  • Kim, Seol-Hee (Department of Food & Nutrition, Research Institute of Human Ecology, Seoul Notional University) ;
  • Park, Hyun-Woo (Health Product Research Team, Food Research Institute, Amorepacific Corporation R & D Center) ;
  • Kim, Wan-Gi (Health Product Research Team, Food Research Institute, Amorepacific Corporation R & D Center) ;
  • Lee, Yeon-Sook (Department of Food & Nutrition, Research Institute of Human Ecology, Seoul Notional University)
  • 발행 : 2006.12.31
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초록

The study was conducted to investigate the effects of dietary calcium and soy isoflavone on body fat and lipid metabolism in high fat-induced obesity. Four week old female C57/BL6J mice, known as a good model of diet-induced obesity, were fed low Ca and high fat diet for 6 weeks. After induced obesity, mice were divided into six groups according to diets varying calcium contents (0.1 or 1.5%) and genistein contents (0 or 500 or 1,000 ppm). Body weight, fat pad (perirenal fat and parameterial fat), adipocyte size, serum total lipid and total cholesterol were significantly decreased by both high Ca intake and genistein supplementation. However, the effect of genistein supplementation showed in low Ca-fed groups. Serum LDL-cholesterol and TG were significantly decreased by high Ca intake and genistein supplementation, respectively. In liver, lipogenic enzymes (fatty acid synthase and malic enzyme) activity and TG were significantly decreased by both high Ca intake and genistein supplementation. This inhibitory effect of genistein on lipogenic enzymes showed in low Ca-fed groups. But liver total cholesterol and total lipid were significantly decreased by high Ca intake and genistein supplementation, respectively. Fecal excretion of total lipid, total cholesterol and TG were significantly increased by high Ca intake, not by genistein supplementation. In conclusion, high calcium intake and genistein supplement may be beneficial for suppression of obesity through direct anti-adipogenesis by decreasing fat weight and size and indirect anti-lipo-genesis by inhibiting lipogenic enzymes activity and improving lipid profile.

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