Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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The Effects of Thiopental, Propofol, Etomidate and Diazepam-Ketamine Combination on Isoflurane Anesthesia in Dogs

개의 Isoflurane 흡입마취 시 Thiopental, Propofol, Etomidate 및 Diazepam-Ketamine 병용투여의 영향

  • Lee, Jae-Yeon (College of Veterinary Medicine.Research Institute of Veterinary Medicine Chungnam National University) ;
  • Jee, Hyun-Chul (College of Veterinary Medicine.Research Institute of Veterinary Medicine Chungnam National University) ;
  • Kim, Myung-Cheol (College of Veterinary Medicine.Research Institute of Veterinary Medicine Chungnam National University) ;
  • Jeong, Seong-Mok (College of Veterinary Medicine.Research Institute of Veterinary Medicine Chungnam National University)
  • 이재연 (충남대학교 수의과대학.동물의과학 연구소) ;
  • 지현철 (충남대학교 수의과대학.동물의과학 연구소) ;
  • 김명철 (충남대학교 수의과대학.동물의과학 연구소) ;
  • 정성목 (충남대학교 수의과대학.동물의과학 연구소)
  • Published : 2006.12.30
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Abstract

This study was performed to compare propofol, thiopental, etomidate and diazepam plus ketamin as induction agents for the isoflurane anesthesia in dogs. Experimental groups were divided into low groups (thiopental group: thiopental 15 mg/kg IV, propofol group: propofol mg/kg IV, etomidate group: etomidate 1.5 mg/kg IV, DZP+KET group: diazepam 0.5 mg/kg + ketamine 5 mg/kg, IV) and each group was consisted of 4 dogs. Cardiorespiratory changes (heart rate, $SpO_2$, respiratory rate, End-tidal $CO_2$ and body temperature), blood serum chemistry values (alkaline phosphatase, alanine aminotransforase, and total protein), and recovery and walking time were measured. The end tidal carbon dioxide level was significantly increased in the thiopental group (P<0.05). Heart rate and respiratory rate higher in the DZP+KET groups. There was hypothermia in all groups and significant decrease in body temperature was showed in thiopental group (p<0.05). Mean arousal time and mean walking time were significantly longer in thiopental group (P<0.05). Cardiovascular stimulating effects were minimal in etomidate group. Etomidate provides uneventful and rapid recovery.

Keywords

References

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