생약학회지 (Korean Journal of Pharmacognosy)

  • 제37권3호
  • /
  • Pages.212-216
  • /
  • 2006
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

천연물제제 마루플랜트$-AMP-365^{TM}$의 항염증 및 면역활성에 미치는 영향

Anti-inflammatory and Immunomodulatory Effects of the Botanical Product $AMP-365^{TM}$

  • 신은명 (서울대학교 약학대학 천연물과학연구소) ;
  • 김동현 (경희대학교 약학대학) ;
  • 권영복 ((주)아토마루) ;
  • 김영식 (서울대학교 약학대학 천연물과학연구소)
  • Shin, Eun-Myoung (National Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Kim, Dong-Hyun (College of Pharmacy Kyung Hee University) ;
  • Kwon, Young-Bok (Atomaru Co., Gapyeong-gun) ;
  • Kim, Yeong-Shik (National Products Research Institute, College of Pharmacy, Seoul National University)
  • 발행 : 2006.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The effect of aqueous extracts of medicinal plants $AMP-365^{TM}$ was tested for immune system regulating activity based on anti-inflammatory activity, anti-oxidant, macrophage proliferation and T-lymphocyte proliferation activity. $AMP-365^{TM}$ dose-dependently increased proliferation of RAW264.7 macrophage cells and its nitric oxide production as well as DPPH radical scavenging activity. On the other hand, T-lymphocyte proliferation activity was decreased on dose-dependent manner. Passive cutaneous anaphylaxis reaction was alleviated by 49% by administering 250 mg/kg of $AMP-365^{TM}$. The results suggest that $AMP-365^{TM}$ can be beneficial in the treatment of immediate allergic reactions as an adjuvant supplement material.

키워드

참고문헌

  1. Pharham, P. (2005), The Immune System. Garland Science, New York
  2. Toyokuni, S., Tanaka, T., Kawaguchi, W., Fang, N.R., Ozeki, M., Akatsuka, S., Hiai B., Aruoma O.I., and Bahorun T. (2003) Effects of the phenolic contents of Mauritian endemic plant extracts on promoter activities of antioxidant enzymes. Free Radic Res. 37: 1215-1224 https://doi.org/10.1080/10715760310001598150
  3. Maldonado, P.D., Rivero-Cruz, I., Mata, R., and Pedraza-Chaverri, J. (2005) Antioxidant activity of A-type proanthocyanidins from Geranium niveum (Geraniaceae). J. Agric. Food Chem. 53: 1996-2001 https://doi.org/10.1021/jf0483725
  4. Liu, C.T., Chuang, P.T., Wu, C.Y., Weng, Y.M., Chen, W., and Tseng, C.Y. (2006) Antioxidative and In Vitro hepatoprotective activity of Bupleurum kaoi leaf infusion. Phytother Res. (in press)
  5. Akdis, C.A., Akdis M., Trautmann, A., and Blaser K. (2000) Immune regulation in atopic dermatitis. Curr Opin Immunol 12: 641-646 https://doi.org/10.1016/S0952-7915(00)00156-4
  6. Rudikoff, D. and Lebwohl, M. (1998) Atopic dermatitis. Lancet 351: 1715-1721 https://doi.org/10.1016/S0140-6736(97)12082-7
  7. Ackerman, S.J., Loegering, D.A., Venge, P., Olsson, I., Harley, J.B., Fauci, A.S., and Gleich, G.J. (1983) Distinctive cationic proteins of the human eosinophil granule: major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin. J. Immunol 131: 2977-2982
  8. Venge, P. (1993) Eosinophil and neutrophil granulocytes. Allergy 48(Suppl. 17): 39-47; discussion 48-49 https://doi.org/10.1111/j.1398-9995.1993.tb04697.x
  9. Ahn, K.S., Noh, E.J., Zhao, H.L., Jung, S.H., Kang, S.S., and Kim Y.S. (2005) Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells. Life Sci. 76: 2315-2328 https://doi.org/10.1016/j.lfs.2004.10.042
  10. Yokozawa, T., Chen, C. P., Dong, E., Tanaka, T., Nonaka, GI., and Nishioka, I. (1998) Study on the inhibitory effect of tannins and flavonoids against the 1,1-diphenyl-2 picrylhydrazyl radical. Biochem Pharmacal 56: 213-222 https://doi.org/10.1016/S0006-2952(98)00128-2
  11. Shim, J.Y., Lee,Y.S., Jung S.H., Choi, H.S., Shin, K.H., and Kim, Y.S. (2002) Pharmacological activities of a new glycosarninoglycan, acharan sulfate isolated from the giant African snail Achatina fulica. Arch. Pharm. Res. 25: 889-894 https://doi.org/10.1007/BF02977010
  12. Inagaki, N., Nagao, M., Igeta, K., Kawasaki, H., Kim, J.F., and Nagai, H. (2001) Scratching behavior in various strains of mice. Skin Pharmacal Appl. Skin Physiol 14: 87-96
  13. Kimata, M., Shichijo, M., Miura, T., Serizawa, I., Inagaki, N., and Nagai, H. (2000) Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin Exp. Allergy 30: 501-508 https://doi.org/10.1046/j.1365-2222.2000.00768.x
  14. Tenda, Y., Yamashita, M., Kimura, M.Y., Hasegawa, A. Shimizu, C, Kitajima, M., Onodera, A, Suzuki, A, Seki, N., and Nakayama, T. (2006) Hyperresponsive Th2 cells with enhanced nuclear factor-kB activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice. J Allergy Clin Immunol 118: 725-723 https://doi.org/10.1016/j.jaci.2006.05.024
  15. 고재숙, 하병조, 강승주, 고혜정, 장경자 (2000) 피부과학, 수문사 pp.107-118